3900-46-7

Basic information

• Product Name: N-(6-methoxynaphthalen-2-yl)acetamide
• CAS NO: 3900-46-7
• Molecular Formula: C₁₃H₁₃NO₂
• Molecular Weight: 215.2478
• Mol File: 3900-46-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 446.4°C at 760 mmHg
• Flash Point: 223.7°C
• Density: 1.191g/cm³
• Vapor Pressure: 3.67E-08mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: N-(6-methoxynaphthalen-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-methoxynaphthalen-2-yl)acetamide(3900-46-7)
• EPA Substance Registry System: N-(6-methoxynaphthalen-2-yl)acetamide(3900-46-7)

Safety Data

• Hazardous Substances Data: 3900-46-7(Hazardous Substances Data)

Upstream product

• 6610-10-2 N-(6-hydroxy-[2]naphthyl)-acetamide 
• 77-78-1 dimethyl sulfate 
• 13101-88-7 6-methoxy-2-naphthylamine 
• 93-04-9 2-Methoxynaphthalene 
• 64-19-7 acetic acid 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 
• 3893-38-7 1-(6-methoxynaphthalen-2-yl)ethanone oxime 
• 60-29-7 diethyl ether 
• 10026-13-8 phosphorus pentachloride 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 

Downstream Products

• 13101-88-7 6-methoxy-2-naphthylamine 
• 59115-43-4 2-methoxy-6-phenylnaphthalene 
• 475278-17-2 6-phenylnaphthalen-2-ol 
• 13101-89-8 6-Fluor-2-methoxy-naphthalin 

Relevant articles and documents

Radical Beckmann Rearrangement and Its Application in the Formal Total Synthesis of Antimalarial Natural Product Isocryptolepine via C-H Activation

The Beckmann rearrangement of ketoximes, mediated by ammonium persulfate-dimethyl sulfoxide as a reagent, has been achieved under neutral conditions. Based on the radical trapping and 18O-labeling experiments, the transformation follows a mechanism involving a radical pathway. The scope and generality of the developed protocol has been demonstrated by 19 examples. The developed protocol and Pd-catalyzed intramolecular double C-H activation were used as key steps in the formal total synthesis of antimalarial natural product isocryptolepine.

Schmidt reaction of ketones in dme solution in a continuous-flow microreactor

The Schmidt reaction, the treatment with hydroazoic acid in the presence of a strong acid, converts ketones to amides directly and has been broadly applied in organic synthesis. In this communication, the Schmidt reaction of ketones was carried out in DME solution in a continuous-flow microreactor and gave the amide products. The enclosed small-volume feature of the microreactor made this reaction safe, fast, and cost-effective.