39022-48-5Relevant academic research and scientific papers
Sulfur-Promoted Aminative Aromatization of 1,2,3,4-Tetrahydrophenazines with Amines: Flexible Access to 1-Aminophenazines
Nguyen, Thanh Binh,Retailleau, Pascal
, p. 2389 - 2393 (2018)
Elemental sulfur was found to be an excellent reagent for promoting the aminative aromatization of 1,2,3,4-tetrahydrophenazines with amines to provide a wide range of functionalized 1-aminophenazines. (Figure presented.).
Synthesis of 1-substituted phenazines as novel antichlamydial agents
Bao, Xiao-Feng,Jiang, He,Liu, Zi-Yi,Xie, Wen-Xia,Zhao, Yu,Zhu, Li,Zhu, Yi-Xin
, (2021/10/21)
A novel series of 1-substituted phenazines 4a-4l were designed and synthesized via Palladium-catalyzed reactions from 1-phenazine trifluoromethanesulfonate. These phenazines showed antichlamydial activity with IC50 values from 1 to 10 μM. Among them, compounds 4c and 4i exhibited the best antichlamydial activity with IC50 values from 2.06 to 2.74 μM without apparent cytotoxicity to host cells.
Phenazine derivative with nitrogen-containing side chain, and preparation method and application thereof
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Paragraph 0045; 0047-0048; 0052-0054, (2020/07/13)
The invention belongs to the technical field of medicinal chemistry and pharmacology, and discloses a phenazine derivative with a nitrogen-containing side chain, and a preparation method and application thereof. The phenazine derivative has a chemical str
