39030-46-1

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[(4-chlorophenyl)methoxy]-
• CAS NO: 39030-46-1
• Molecular Formula: C15H10ClNO3
• Molecular Weight: 287.702
• Mol File: 39030-46-1.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(4-chlorophenyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[(4-chlorophenyl)methoxy]-(39030-46-1)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[(4-chlorophenyl)methoxy]-(39030-46-1)

Safety Data

• Hazardous Substances Data: 39030-46-1(Hazardous Substances Data)

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 17698-09-8 2-[(hydroxyamino)carbonyl]benzoic acid 
• 85-44-9 phthalic anhydride 
• 106-43-4 para-chlorotoluene 
• 104-88-1 4-chlorobenzaldehyde 
• 622-95-7 4-chlorobenzyl bromide 
• 873-76-7 para-Chlorobenzyl alcohol 

Downstream Products

• 136918-14-4 phthalimide 
• 104-88-1 4-chlorobenzaldehyde 
• 38936-60-6 O-(4-chlorobenzyl)hydroxylamine hydrochloride 
• 101103-30-4 N,N'-Bis-(4-chlor-benzyloxy)-harnstoff 
• 36938-77-9 (pyridin-4-yl)-(4-chlorophenyl)methanol 
• 1542915-15-0 N¹-(adamant-2-yl)-N²-(4-chlorobenzyloxy)oxalamide 
• 1446945-95-4 C₁₈H₂₂ClN₃O₃ 
• 1446946-08-2 C₁₈H₂₄ClN₃O₄ 
• 681145-54-0 2-[2-(4-chloro-benzyloxyamino)-ethyl]-isoindole-1,3-dione 
• 681153-23-1 1-(4-chloro-benzyloxy)-4,5-dihydro-1H-imidazole-2-thiol 
• 681151-76-8 N-(2-amino-ethyl)-O-(4-chloro-benzyl)-hydroxylamine 

Relevant articles and documents

Synthesis, Crystal Structure, Herbicidal Activity, and SAR Study of Novel N-(Arylmethoxy)-2-chloronicotinamides Derived from Nicotinic Acid

Nicotinic acid, also known as niacin, is a natural product, which is widely found in plants and animals. To discover novel natural-product-based herbicides, a series of N-(arylmethoxy)-2-chloronicotinamides were designed and synthesized. Some of the new N-(arylmethoxy)-2-chloronicotinamides exhibited excellent herbicidal activity against Agrostis stolonifera (bentgrass) at 100 μM. Compound 5f (2-chloro-N-((3,4-dichlorobenzyl)oxy)nicotinamide) possessed excellent herbicidal activity against Lemna paucicostata (duckweed), with an IC50 value of 7.8 μM, whereas the commercial herbicides clomazone and propanil had values of 125 and 2 μM, respectively. The structure-activity relationships reported in this paper could be used for the development of new herbicides against monocotyledonous weeds.

Vinylogous Aza-Michael Addition of Urea Derivatives with p-Quinone Methides Followed by Oxidative Dearomative Cyclization: Approach to Spiroimidazolidinone Derivatives

Herein, we report an efficient protocol for the synthesis of spiro-imidazolidinone-cyclohexadienones from p-quinone methides (p-QMs) and dialkyloxy ureas under mild conditions. The strategy follows a two-step process involving an initial vinylogous conjugate addition of urea derivatives to p-QMs, followed by oxidative dearomative cyclization of open-chain product to the projected spiro-imidazolidinones. This protocol exhibits good functional group tolerance and provides a straightforward method to access spiro-imidazolidinone-cyclohexadienones. In follow-up chemistry, we have shown the debenzylation of spiroimidazolidinones to give N-hydroxycyclic ureas. (Figure presented.).

Palladium-catalyzed regio- And stereoselective access to allyl ureas/carbamates: Facile synthesis of imidazolidinones and oxazepinones

Typically, transition metal catalysis enforces the stereodefined outcome of a reaction. Here we disclose the palladium-catalyzed regio- and stereoselective access to allylic ureas/carbamates and their further exploitation to diverse cyclic structures under operationally simple reaction conditions. This protocol features palladium-catalyzed decarboxylative amidation of highly modular VECs with good to excellent yield, minimal waste production, wide substrate scope, and low catalyst loading. In follow-up chemistry, we demonstrated the debenzylation of vinylic imidazolidinones to N-hydroxycyclic ureas and regioselective derivatization towards the facile synthesis of halohydrins and oxiranes under mild reaction conditions in good to excellent yields. This journal is