39065-49-1

Basic information

• Product Name: 2-PHENYL-3-CYANOPYRIDINE
• Synonyms: 2-PHENYL-3-CYANOPYRIDINE;3-Cyano-2-phenylpyridine;2-phenylnicotinonitrile;2-Phenylpyridine-3-carbonitrile
• CAS NO: 39065-49-1
• Molecular Formula: C₁₂H₈N₂
• Molecular Weight: 180.20532
• Mol File: 39065-49-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 351.2°C at 760 mmHg
• Flash Point: 122.2°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 4.18E-05mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PHENYL-3-CYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-3-CYANOPYRIDINE(39065-49-1)
• EPA Substance Registry System: 2-PHENYL-3-CYANOPYRIDINE(39065-49-1)

Safety Data

• Hazardous Substances Data: 39065-49-1(Hazardous Substances Data)

Usage

General Description

2-PHENYL-3-CYANOPYRIDINE is a chemical compound with the molecular formula C12H8N2. It is a heterocyclic aromatic compound with a pyridine ring substituted with a phenyl group and a cyano group. 2-PHENYL-3-CYANOPYRIDINE is used in organic synthesis and can be employed as a starting material or intermediate in the production of various pharmaceuticals and agrochemicals. Its unique structure and properties make it useful in the development of new drugs and other biologically active compounds. Additionally, it has potential applications in the field of material science and as a catalyst in chemical reactions. However, it is important to handle and use this compound with caution, as it may pose hazards to human health and the environment.

InChI:InChI=1/C12H8N2/c13-9-11-7-4-8-14-12(11)10-5-2-1-3-6-10/h1-8H

Upstream product

• 100-54-9 pyridine-3-carbonitrile 
• 98-80-6 phenylboronic acid 
• 614-16-4 Benzoylacetonitrile 
• 289-96-3 1,2,3-triazine 
• 66003-76-7 Diphenyliodonium triflate 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 100-58-3 phenylmagnesium bromide 
• 109674-45-5 4-methyl-2,6-dioxo-8-phenylhexahydro-[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide 

Downstream Products

• 33421-39-5 2-phenyl-3-pyridinecarboxylic acid 
• 3882-46-0 5H-indeno[1,2-b]pyridin-5-one 
• 439118-23-7 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide N-oxide 
• 439118-21-5 4-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide 

Relevant articles and documents

Access to pyridines via cascade nucleophilic addition reaction of 1,2,3-triazines with activated ketones or acetonitriles

We studied the cascade nucleophilic addition reactions of 1,2,3-triazines with activated acetonitriles or ketones, which were used to construct highly substituted pyridines that are not easily accessed by conventional methods. The strategy addressed some structural diversity issues currently facing medicinal chemistry, and the resulting pyridines could be used as convenient precursors for the synthesis of related pharmaceuticals. In particular, our method was applied to the syntheses of the marketed drug etoricoxib and several biologically important molecules in a few steps.

Transition-Metal-Free Synthesis of Pyridine Derivatives by Thermal Cyclization of N -Propargyl Enamines

A transition-metal-free synthesis of pyridine derivatives by 6- endo - dig cyclization of N -propargyl enamines was developed. This method is environmentally friendly and is a high atom economy reaction that is easily accessed to provide pyridine derivatives in moderate to good yield by heating N -propargyl enamines in solvent without additives. The total synthesis of onychine was achieved in 51% yield in only two steps by using this method.

Arylation, Vinylation, and Alkynylation of Electron-Deficient (Hetero)arenes Using Iodonium Salts

Arylation, vinylation, and alkynylation of electron-deficient arenes and heteroarenes have been achieved by chemoselective C-H zincation followed by copper-catalyzed coupling reactions using iodonium salts. This approach offers a direct and general access to a wide scope of (hetero)biaryls as well as alkenylated and alkynylated heteroarenes under mild conditions. It is particularly useful and valuable for the rapid and modular synthesis of diverse (hetero)aryl compounds, as demonstrated in the synthesis of transient receptor potential vanilloid 1 (TRPV1) antagonists and angiotensin II receptor type 1 (AT1 receptor) antagonists.