390816-44-1

Basic information

• Product Name: Methyl 5-Methoxy-6-nitropicolinate
• Synonyms: Methyl 5-Methoxy-6-nitropicolinate;2-Pyridinecarboxylic acid, 5-Methoxy-6-nitro-, Methyl ester;5-Methoxy-6-nitropyridine-2-carboxylic acid methyl ester
• CAS NO: 390816-44-1
• Molecular Formula: C₈H₈N₂O₅
• Molecular Weight: 212.15952
• Mol File: 390816-44-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 380.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.356±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -3.24±0.10(Predicted)
• CAS DataBase Reference: Methyl 5-Methoxy-6-nitropicolinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-Methoxy-6-nitropicolinate(390816-44-1)
• EPA Substance Registry System: Methyl 5-Methoxy-6-nitropicolinate(390816-44-1)

Safety Data

• Hazardous Substances Data: 390816-44-1(Hazardous Substances Data)

Usage

General Description

Methyl 5-methoxy-6-nitropicolinate is a chemical compound with the molecular formula C8H8N2O5. It is a derivative of picolinic acid and contains a nitro and methoxy group, making it a nitro-substituted compound. This chemical is often used in organic synthesis and medicinal chemistry as a building block for the synthesis of more complex molecules. It may also have potential applications in the development of pharmaceuticals and agrochemicals. Overall, methyl 5-methoxy-6-nitropicolinate is an important intermediate compound with various potential uses in the field of chemistry and drug discovery.

Upstream product

• 186581-53-3 diazomethane 
• 24015-98-3 3-methoxy-6-methyl-2-nitro-pyridine 
• 324028-85-5 5-methoxy-6-nitropyridine-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 

Downstream Products

• 390816-45-2 5-cyclohexylamino-6-nitro-pyridine-2-carboxylic acid methyl ester 
• 1072077-54-3 6-amino-5-methoxy-pyridine-2-carboxylic acid methyl ester 
• 1202159-12-3 C₁₅H₁₅N₃O₅ 
• 1202159-14-5 C₁₆H₁₇N₃O₆ 
• 1202159-09-8 C₁₅H₁₅N₃O₄ 
• 1202159-08-7 C₁₄H₁₉N₃O₄ 
• 1202159-10-1 C₁₄H₁₃N₃O₄ 
• 1202159-16-7 C₁₅H₁₂F₃N₃O₅ 

Relevant articles and documents

Discovery and optimization of antibacterial AccC inhibitors

The biotin carboxylase (AccC) is part of the multi-component bacterial acetyl coenzyme-A carboxylase (ACCase) and is essential for pathogen survival. We describe herein the affinity optimization of an initial hit to give 2-(2-chlorobenzylamino)-1-(cyclohe

Viral polymerase inhibitors

An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I: wherein R1 is selected from: H, haloalkyl, (C1-6)alkyl, (C2-6)alkenyl, (C3-7)cycloalkyl, (C2-6)alkynyl, (C5-7)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted; R2 is selected from (C1-6)alkyl, (C3-7)cycloalkyl, (C6-10)bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted; B is N or CR5, wherein R5 is H, halogen, haloalkyl, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; X is N or CR5; D is N or CR5; each of Y1 and Y2 is independently O or S; Z is O, N, or NRz wherein Rz is H, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; R3 and R4 are each independently H, (C1-6)alkyl, first (C3-7)cycloalkyl or 6- or 10-membered aryl, Het (C1-6)alkyl-6- or 10-membered aryl, (C1-6)alkyl-Het; or each R3 and R4 are independently covalently bonded together to form second (C3-7)cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R3 or R4 are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R7 is H, (C1-6 alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; or R7 is covalently bonded to either of R3 or R4 to form a heterocycle; A is (C1-6) alkyl-CONHR8 wherein R8 is-6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.