391-93-5

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER is used as a building block for the preparation of various pharmaceutical products. Its unique chemical structure makes it a valuable component in the synthesis of drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER is utilized as an intermediate in the synthesis of agrochemicals, contributing to the development of effective products for agricultural use.
Used in Research and Development:
2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER is employed as a key component in the research and development of new drugs. Its properties and reactivity make it a promising candidate for the creation of innovative pharmaceutical compounds with potential therapeutic benefits.
Safety Considerations:
It is essential to handle 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER with care and adhere to proper safety protocols when working with it in a laboratory setting. This ensures the safety of researchers and the integrity of the experiments conducted.

Upstream product

• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 64-17-5 ethanol 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 364-51-2 ethyl 5-fluoro-2-nitrobenzoate 

Downstream Products

• 168900-02-5 3-(2,4-dichlorophenyl)-6-fluoro-2,4(1H,3H)-quinazolinedione 
• 16499-45-9 7-fluoroquinazoline 
• 113082-27-2 2-chloro-6-fluoroquinazoline 
• 1085458-48-5 C₈H₅FN₂O 
• 153501-10-1 ethyl 5-fluoro-3-hydroxyindole-2-carboxylate 
• 190433-36-4 ethyl N-[4-fluoro-2-(ethoxycarbonyl)phenyl]glycinate 

Relevant academic research and scientific papers

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

RE[N(SiMe3)2]3-Catalyzed Guanylation/Cyclization of Amino Acid Esters and Carbodiimides

The example of rare-earth metal-catalyzed guanylation/cyclization of amino acid esters and carbodiimides is well-established, forming 4(3H)-2-alkylaminoquinazolinones in 65-96% yields. The rare-earth metal amides RE[N(TMS)2]3 (RE = Y, Yb, Nd, Sm, La; TMS = SiMe3) showed high activities, and La[N(TMS)2]3 performed best for a wide scope of the substrates.

Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives

Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation is considered a potential powerful tool in regenerative medicine to treat severe tissue injuries. Starting from GSA-10, a recently reported Hh activator acting on Smo, we have designed and synthesized a new class of quinolone-based compounds. Modification and decoration of three different portions of the original scaffold led to compounds able to induce differentiation of multipotent mesenchymal cells into osteoblasts. The submicromolar activity of several of these new quinolones (0.4–0.9?μM) is comparable to or better than that of SAG and purmorphamine, two reference Smo agonists. Structure-activity relationships allow identification of several molecular determinants important for the activity of these compounds.

Quinolone compounds for use in treating viral infections

The present invention relates to quinolone compounds and their use in the treatment of viral infections.

Process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid

The present invention relates to a process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid, which comprises dissolving a 3-fluorobenzoic alkyl ester in sulfuric acid and reacting the solution with a nitrating acid at from -10° to 30° C., then adding water, separating off the nitrated reaction product and reacting it with hydrogen at from 50° to 120° C. under elevated pressure in the presence of a catalyst comprising a metal of the platinum group and sulfur, and, if desired, removing 5-fluoroanthranilic alkyl esters by distillation and hydrolyzing them to give 5-fluoroanthranilic acid.