391-93-5

Basic information

• Product Name: 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER
• Synonyms: UKRORGSYN-BB BBV-199988;Benzoic acid, 2-aMino-5-fluoro-, ethyl ester;2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER
• CAS NO: 391-93-5
• Molecular Formula: C₉H₁₀FNO₂
• Molecular Weight: 183.18
• Product Categories: Aromatic Esters
• Mol File: 391-93-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER(391-93-5)
• EPA Substance Registry System: 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER(391-93-5)

Safety Data

• Hazardous Substances Data: 391-93-5(Hazardous Substances Data)

Usage

General Description

2-Amino-5-fluorobenzoic acid ethyl ester is a chemical compound with the molecular formula C9H9NO2F. It is a derivative of 2-amino-5-fluorobenzoic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a white to off-white solid and is soluble in organic solvents such as ethanol and methanol. 2-AMINO-5-FLUOROBENZOIC ACID ETHYL ESTER is used as a building block in the preparation of various pharmaceutical products, and it has applications in the research and development of new drugs. It is important to handle this chemical with care and follow proper safety protocols when working with it in a laboratory setting.

Upstream product

• 64-17-5 ethanol 
• 446-08-2 2-amino-5-fluorobenzoic acid 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 364-51-2 ethyl 5-fluoro-2-nitrobenzoate 

Downstream Products

• 190433-36-4 ethyl N-[4-fluoro-2-(ethoxycarbonyl)phenyl]glycinate 
• 153501-10-1 ethyl 5-fluoro-3-hydroxyindole-2-carboxylate 
• 168900-02-5 3-(2,4-dichlorophenyl)-6-fluoro-2,4(1H,3H)-quinazolinedione 
• 1085458-48-5 C₈H₅FN₂O 
• 113082-27-2 2-chloro-6-fluoroquinazoline 
• 16499-45-9 7-fluoroquinazoline 

Relevant articles and documents

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives

Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation is considered a potential powerful tool in regenerative medicine to treat severe tissue injuries. Starting from GSA-10, a recently reported Hh activator acting on Smo, we have designed and synthesized a new class of quinolone-based compounds. Modification and decoration of three different portions of the original scaffold led to compounds able to induce differentiation of multipotent mesenchymal cells into osteoblasts. The submicromolar activity of several of these new quinolones (0.4–0.9?μM) is comparable to or better than that of SAG and purmorphamine, two reference Smo agonists. Structure-activity relationships allow identification of several molecular determinants important for the activity of these compounds.

Process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid

The present invention relates to a process for the preparation of 5-fluoroanthranilic alkyl esters and/or 5-fluoroanthranilic acid, which comprises dissolving a 3-fluorobenzoic alkyl ester in sulfuric acid and reacting the solution with a nitrating acid at from -10° to 30° C., then adding water, separating off the nitrated reaction product and reacting it with hydrogen at from 50° to 120° C. under elevated pressure in the presence of a catalyst comprising a metal of the platinum group and sulfur, and, if desired, removing 5-fluoroanthranilic alkyl esters by distillation and hydrolyzing them to give 5-fluoroanthranilic acid.