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391239-25-1

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391239-25-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 391239-25-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,1,2,3 and 9 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 391239-25:
(8*3)+(7*9)+(6*1)+(5*2)+(4*3)+(3*9)+(2*2)+(1*5)=151
151 % 10 = 1
So 391239-25-1 is a valid CAS Registry Number.

391239-25-1Downstream Products

391239-25-1Relevant articles and documents

Design of fluorine-containing 3,4-diarylfuran-2(5H)-ones as selective COX-1 inhibitors

Uddin, Md. Jashim,Elleman, Anna V.,Ghebreselasie, Kebreab,Daniel, Cristina K.,Crews, Brenda C.,Nance, Kellie D.,Huda, Tamanna,Marnett, Lawrence J.

, p. 1254 - 1258 (2014)

We report the design and synthesis of fluorine-containing cyclooxygenase-1 (COX-1)-selective inhibitors to serve as prototypes for the development of a COX-1-targeted imaging agent. Deletion of the SO2CH3 group of rofecoxib switches the compound from a COX-2- to a COX-1-selective inhibitor, providing a 3,4-diarylfuran-2(5H)-one scaffold for structure-activity relationship studies of COX-1 inhibition. A wide range of fluorine-containing 3,4-diarylfuran-2(5H)-ones were designed, synthesized, and tested for their ability to selectively inhibit COX-1 in purified protein and human cancer cell assays. Compounds containing a fluoro-substituent on the C-3 phenyl ring and a methoxy-substituent on the C-4 phenyl ring of the 3,4-diarylfuran-2(5H)-one scaffold were the best COX-1-selective agents of those evaluated, exhibiting IC50s in the submicromolar range. These compounds provide the foundation for development of an agent to facilitate radiologic imaging of ovarian cancer expressing elevated levels of COX-1.

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