3913-18-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4,6-dimethyl-quinoline is used as a key intermediate in the synthesis of various pharmaceutical compounds for its antimicrobial, antifungal, and antiparasitic properties. Its unique structure and reactivity contribute to the development of new drugs with improved efficacy and safety profiles.
Used in Antimicrobial Applications:
2-Chloro-4,6-dimethyl-quinoline is employed as an antimicrobial agent, targeting a wide range of bacteria and inhibiting their growth and proliferation. Its potential use in the development of new antibiotics can help address the growing issue of antibiotic resistance.
Used in Antifungal Applications:
2-CHLORO-4,6-DIMETHYL-QUINOLINE is used as an antifungal agent, effective against various fungal species, including Candida and Aspergillus. Its incorporation into antifungal drugs can provide an alternative treatment option for fungal infections, particularly in cases of drug resistance.
Used in Antiparasitic Applications:
2-Chloro-4,6-dimethyl-quinoline is utilized as an antiparasitic agent, showing activity against parasites such as Plasmodium, the causative agent of malaria. Its potential role in promoting antimalarial activities can contribute to the development of new therapies for malaria treatment and prevention.
Used in Medicinal Chemistry and Drug Design:
2-CHLORO-4,6-DIMETHYL-QUINOLINE's structure and reactivity make it a subject of interest in medicinal chemistry and drug design. Researchers can explore its potential in the development of new chemical entities with novel mechanisms of action, leading to the discovery of innovative therapeutic agents.
Used in the Development of New Materials and Chemical Processes:
2-Chloro-4,6-dimethyl-quinoline's unique properties also make it a valuable component in the development of new materials and chemical processes. Its potential applications in various industries, such as agriculture, textiles, and environmental management, can lead to the creation of more effective and sustainable solutions.

InChI:InChI=1/C11H10ClN/c1-7-3-4-10-9(5-7)8(2)6-11(12)13-10/h3-6H,1-2H3

Upstream product

• 23947-37-7 2-hydroxy-6-methyllepidine 
• 106-49-0 p-toluidine 
• 2415-85-2 3-oxo-N-(p-tolyl)butanamide 
• 23947-37-7 4,6-dimethylquinolin-2(1H)-one 

Downstream Products

• 110146-13-9 N-(4,6-dimethyl-[2]quinolyl)-anthranilic acid methyl ester 
• 826-77-7 4,6-dimethylquinoline 
• 158470-92-9 4,6-dimethyl-2-(4-methyl-2-nitroanilino)quinoline 
• 258521-44-7 2-(4-methoxy-2-nitroanilino)-4,6-dimethylquinoline 
• 1026008-36-5 N¹-(4,6-Dimethyl-quinolin-2-yl)-4-methyl-benzene-1,2-diamine 
• 158470-95-2 2,5,9,11-tetramethyl-5H-indolo<2,3-b>quinoline 
• 936008-06-9 2-(3-methylphenyl)-4,7-dimethylquinoline 
• 952443-34-4 (S)-1-(3-(4,6-dimethylquinolin-2-ylamino)pyrrolidin-1-yl)-2-(4-trifluoromethoxyphenyl)ethanone 
• 1315380-30-3 2[(2'-acetylphenyl)amino]-4,6-dimethylquinoline 
• 295344-84-2 4,6-dimethyl-2-(4'-methyl-phenylamino)quinoline 
• 1315380-24-5 2-(2,9-dimethyl-12-phenyldibenzo[b,g][1,8]naphthyridin-11(6H)-ylidene)-1-phenylethanone 
• 1315379-93-1 4,6-dimethyl-2-(4'-chloro-phenylamino)quinoline 
• 1315380-13-2 2-(2-chloro-9-methyl-12-phenyldibenzo[b,g][1,8]naphthyridin-11(6H)-ylidene)-1-phenylethanone 
• 1315379-97-5 2[(2'-benzoyl-4'-chlorophenyl)amino]-4,6-dimethylquinoline 

Relevant academic research and scientific papers

Compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds

The invention provides 7-substituted-5-methyl-1,2,4-triazolo[4,3-a] quinoline and 7-substituted-5-ethoxy-[1,2,4]-triazolo[4,3-a] quinoline compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds in the field of preparing anticonvulsion medicines.

Diastereoselective hydrogenation of substituted quinolines to enantiomerically pure decahydroquinolines

The stereoselective hydrogenation of auxiliary-substituted quinolines was used to build up saturated and partially saturated heterocycles. In a first step, the formation and diastereoselective hydrogenation of 2-oxazolidinone- substituted quinolines to 5,6,7,8-tetrahydroquinolines is reported. In this unprecedented process, stereocenters on the carbocyclic quinoline ring were formed with a dr of up to 89:11. Platinum oxide as a catalyst and trifluoroacetic acid as a solvent were found to be optimal for high levels of chemo- and stereoselectivity in this step. In a second hydrogenation step, the completely saturated decahydroquinolines with 4 newly formed stereocenters were obtained with enantioselectivities of up to 99%. Rhodium on carbon as a catalyst and acetic acid as a solvent gave the best results for this hydrogenation and allowed a traceless cleavage of the chiral auxiliary. Thus, this new method allows an efficient stereoselective synthesis of valuable 5,6,7,8-tetrahydro- and decahydroquinoline products.

Quinoline antifolate thymidylate synthase inhibitors: Variation of the C2- and C4-substituents

Modifications to the bicyclic ring system of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6- quinazolinyl)methyl]-N-prop-2-ynylamino]benzoyl]-L-glutamic acid (1, CB3717) have led to the synthesis of a series of quinol