826-77-7

Basic information

• Product Name: 4,6-dimethylquinoline
• Synonyms: 4,6-dimethylquinoline
• CAS NO: 826-77-7
• Molecular Formula: C₁₁H₁₁N
• Molecular Weight: 157.21174
• EINECS: 212-561-0
• Mol File: 826-77-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 22°C
• Boiling Point: 273.55°C
• Flash Point: 114°C
• Appearance: /
• Density: 1.0577
• Vapor Pressure: 0.00893mmHg at 25°C
• Refractive Index: 1.6100
• PKA: 5.87±0.16(Predicted)
• CAS DataBase Reference: 4,6-dimethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dimethylquinoline(826-77-7)
• EPA Substance Registry System: 4,6-dimethylquinoline(826-77-7)

Safety Data

• Hazardous Substances Data: 826-77-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11N/c1-8-3-4-11-10(7-8)9(2)5-6-12-11/h3-7H,1-2H3

Upstream product

• 3913-18-6 2-chloro-4,6-dimethylquinoline 
• 50-00-0 formaldehyd 
• 106-49-0 p-toluidine 
• 67-64-1 acetone 
• 540-23-8 p-toluidine hydrochloride 
• 78-94-4 methyl vinyl ketone 
• 18436-71-0 4-chloro-6-methylquinoline 
• 75-16-1 methylmagnesium bromide 
• 23947-37-7 4,6-dimethylquinolin-2(1H)-one 
• 18826-95-4 1.3-butanediol 
• 1384466-89-0 C₁₆H₂₃NO₃ 
• 1384466-88-9 C₁₆H₂₂INO₃ 
• 1017279-68-3 t-butyl (2-iodo-4-methylphenyl)carbamate 
• 23947-37-7 2-hydroxy-6-methyllepidine 

Downstream Products

• 1028758-07-7 6-methyl-4-(4-nitro-trans-styryl)quinoline 
• 7101-68-0 4-methyl-6-quinolinecrboxylic acid 
• 110244-27-4 N,N-dimethyl-4-[trans-2-(6-methyl-[4]quinolyl)-vinyl]-aniline 

Relevant articles and documents

Metal-Free Chemoselective Oxidation of 4-Methylquinolines into Quinoline-4-Carbaldehydes

A convenient protocol for the synthesis of quinoline-4-carbaldehydes via chemoselective oxidation of 4-methylquinolines using hypervalent iodine(III) reagents as oxidant is described. This method highlights metal-free and mild reaction conditions, nice yield, good functional group tolerance, and high chemoselectivity.

Quinolines synthesis by reacting 1,3-butanediol with anilines in the presence of iron catalysts

2-, 4-, 6-, 7-, and 8-substituted quinolines were synthesized in 78–95% yield by the reaction of 1,3- butanediol with anilines in the presence of iron catalysts in carbon tetrachloride.

Solvent-promoted and -controlled Aza-Michael reaction with aromatic amines

(Chemical Equation Presented) 1,4-Addition of anilines onto Michael acceptors proceeds easily in specific polar protic solvents, without any promoting agent. According to the solvent and to the electrophile, the selectivity of the reaction can be finely tuned. With methyl acrylate as electrophile, only monoaddition takes place in water, while the diadduct is yielded in hexafluoroisopropyl alcohol (HFIP). The use of methyl vinyl ketone as a partner affords the monoadduct in water, the diadduct in trifluoroethanol (TFE), and the quinoline in HFIP.