23947-37-7

Basic information

• Product Name: 4,6-DIMETHYLQUINOLIN-2-OL
• Synonyms: 4,6-DIMETHYLQUINOLIN-2-OL;4,6-DIMETHYL-2-HYDROXYQUINOLINE;2(1H)-Quinolinone, 4,6-dimethyl-;4,6-dimethyl-1H-quinolin-2-one;4,6-dimethylcarbostyril;4,6-dimethylquinolin-2(1H)-one
• CAS NO: 23947-37-7
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.22
• Mol File: 23947-37-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 350.9°Cat760mmHg
• Flash Point: 206.5°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 4.26E-05mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: 4,6-DIMETHYLQUINOLIN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DIMETHYLQUINOLIN-2-OL(23947-37-7)
• EPA Substance Registry System: 4,6-DIMETHYLQUINOLIN-2-OL(23947-37-7)

Safety Data

• Hazardous Substances Data: 23947-37-7(Hazardous Substances Data)

Usage

General Description

4,6-DIMETHYLQUINOLIN-2-OL is a chemical compound with the molecular formula C11H11NO. It is a derivative of quinoline and contains a hydroxyl group. The compound is found in some plant species and has been used in research and pharmaceutical applications. It exhibits antioxidant and anti-inflammatory properties, and its structure suggests potential biological activities. Its unique structure and functional groups make it a valuable compound for further study and potential development of new drug compounds.

InChI:InChI=1/C11H11NO/c1-7-3-4-10-9(5-7)8(2)6-11(13)12-10/h3-6H,1-2H3,(H,12,13)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 106-49-0 p-toluidine 
• 124-38-9 carbon dioxide 
• 107859-39-2 2-(2-Amino-5-methylphenyl)-propen 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 2415-85-2 3-oxo-N-(p-tolyl)butanamide 
• 4341-76-8 Ethyl 2-butynoate 
• 103-89-9 4-Methylacetanilide 

Downstream Products

• 53761-42-5 1,4,6-trimethylquinolin-2(1H)-one 
• 826-77-7 4,6-dimethylquinoline 
• 123637-75-2 (S)-2-{4-[(2-Acetylamino-4-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid diethyl ester 
• 123651-23-0 N-[4-[N-(2-amino-4-methylquinolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoyl]-L-glutamic acid 
• 123637-09-2 (S)-2-{4-[(2-Chloro-4-methyl-quinolin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid 
• 3913-18-6 2-chloro-4,6-dimethylquinoline 

Relevant articles and documents

Ru-NHC-Catalyzed Asymmetric Hydrogenation of 2-Quinolones to Chiral 3,4-Dihydro-2-Quinolones

Direct enantioselective hydrogenation of unsaturated compounds to generate chiral three-dimensional motifs is one of the most straightforward and important approaches in synthetic chemistry. We realized the Ru(II)-NHC-catalyzed asymmetric hydrogenation of 2-quinolones under mild reaction conditions. Alkyl-, aryl- and halogen-substituted optically active dihydro-2-quinolones were obtained in high yields with moderate to excellent enantioselectivities. The reaction provides an efficient and atom-economic pathway to construct simple chiral 3,4-dihydro-2-quinolones. The desired products could be further reduced to tetrahydroquinolines and octahydroquinolones.

HFIP-mediated strategy towards β-oxo amides and subsequent Friedel-Craft type cyclization to 2?quinolinones using recyclable catalyst

A simple and cost-effective 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)-mediated protocol for the synthesis of β-oxo amides has been described by using amines and β-keto esters as substrates. The reaction conditions were found to be highly efficient towards the cleavage of C[sbnd]O bond and consequent formation of the products in excellent yields and selectivity. The obtained β-oxo amides were further transformed in to the synthetically useful 2?quinolinones via intramolecular Friedel-Craft type cyclization of aromatic ring using ferrites as a recyclable catalyst. A spectrum of substrates bearing broad range of functional groups were well tolerated under the reaction conditions. The proposed mechanistic pathways were substantially verified by literature and mass-spectroscopic evidences.

Compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds

The invention provides 7-substituted-5-methyl-1,2,4-triazolo[4,3-a] quinoline and 7-substituted-5-ethoxy-[1,2,4]-triazolo[4,3-a] quinoline compounds having anticonvulsion activity, preparing methods thereof and applications of the compounds in the field of preparing anticonvulsion medicines.