391684-36-9 Usage
Description
Boc-NH-PEG(5)-COOH(22atoms), also known as t-Boc-N-amido-PEG6-CH2CO2H, is a heterobifunctional, PEGylated crosslinker with a carboxylic acid at one end and a Boc-protected amino group at the other. The hydrophilic PEG spacer increases solubility in aqueous media, making it suitable for various biological applications.
Uses
Used in Bioconjugation:
Boc-NH-PEG(5)-COOH(22atoms) is used as a crosslinker for bioconjugation, allowing the formation of stable amide bonds between the terminal carboxylic acid and primary amine groups in the presence of activators such as EDC or HATU. This enables the creation of small molecules, conjugates of small molecules and/or biomolecules, and other tool compounds for chemical biology and medicinal chemistry that require ligation.
Used in Chemical Biology and Medicinal Chemistry:
Boc-NH-PEG(5)-COOH(22atoms) is used as a building block for the synthesis of small molecules, conjugates, and other tool compounds in chemical biology and medicinal chemistry. The Boc-protected amino group can be deprotected under mild acidic conditions, providing a free amine for further reactions and applications.
Used in Targeted Protein Degradation:
In the pharmaceutical industry, Boc-NH-PEG(5)-COOH(22atoms) is used as a component in the synthesis of proteolysis-targeting chimeras (PROTAC) molecules for targeted protein degradation. This application takes advantage of the molecule's ability to form stable amide bonds and its solubility in biological systems.
Used in Antibody-Drug Conjugates:
In the field of cancer therapy, Boc-NH-PEG(5)-COOH(22atoms) is used in the synthetic incorporation into antibody-drug conjugates. The hydrophilic PEG spacer and the ability to form stable amide bonds make it an ideal candidate for creating these conjugates, which can improve the delivery and efficacy of chemotherapeutic drugs to cancer cells.
Check Digit Verification of cas no
The CAS Registry Mumber 391684-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,1,6,8 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 391684-36:
(8*3)+(7*9)+(6*1)+(5*6)+(4*8)+(3*4)+(2*3)+(1*6)=179
179 % 10 = 9
So 391684-36-9 is a valid CAS Registry Number.
391684-36-9Relevant articles and documents
IRAK DEGRADERS AND USES THEREOF
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Paragraph 3446; 3450, (2019/07/10)
The present invention provides compounds, compositions thereof, and methods of using the same.
αvβ3 integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligoethylene glycol (OEG) spacers
Rerat, Vincent,Dive, Georges,Cordi, Alex A.,Tucker, Gordon C.,Bareille, Reine,Amédée, Jo?lle,Bordenave, Laurence,Marchand-Brynaert, Jacqueline
supporting information; experimental part, p. 7029 - 7043 (2010/07/05)
RGD peptides are used in biomaterials science for surface modifications with a view to elicit selective cellular responses. Our objective is to replace peptides by small peptidomimetics acting similarly. We designed novel molecules targeting αvβ3 integrin and featuring spacer-arms (for surface grafting), which do not disturb the biological activity, from (L) N-(3-(trifluoromethyl)benzenesulfonyl) tyrosine used as scaffold. Various Arg-mimics were fixed on the phenol function, and the ortho position was used for the coupling of OEG spacers. All peptidomimetics were active in the nM range in a binding test toward human αvβ 3 integrin (IC50 = 0.1 to 1.7 nM) and selective versus platelet integrin αIIbβ3. Selected compounds revealed excellent ability to inhibit bone cells adhesion on vitronectin. Modeling and docking studies were performed for comparing the most active RGD peptidomimetic to cilengitide, i.e., cyclo-[RGDfN(Me)V]-. Lastly, the adhesion of endothelial cells on a cultivation support grafted with RGD peptidomimetics was significantly improved. 2009 American Chemical Society.
