391688-53-2Relevant academic research and scientific papers
Silver-Mediated Oxidative Decarboxylative Trifluoromethylthiolation of Coumarin-3-carboxylic Acids
Li, Minghao,Petersen, Jeffrey L.,Hoover, Jessica M.
supporting information, p. 638 - 641 (2017/02/10)
The introduction of trifluoromethylthio groups into organic compounds, in particular heterocycles, is important because of the prevalence of these structures in medicinally and agriculturally relevant molecules. Herein, the silver-mediated oxidative decarboxylative trifluoromethylthiolation of coumarin-3-carboxylic acids is reported. This methodology utilizes existing carboxylic acid functionalities for the direct conversion to CF3S groups and results in a broad scope of 3-trifluoromethylthiolated coumarins, including analogues of natural products, in moderate to excellent yields.
Microwave-promoted, one-pot, solvent-free synthesis of 4-arylcoumarins from 2-hydroxybenzophenones
Crecente-Campo, Jose,Vazquez-Tato, M. Pilar,Seijas, Julio A.
supporting information; experimental part, p. 4130 - 4135 (2010/09/18)
4-Arylcoumarins are synthesized in very good yields through solvent-free microwave irradiation of 2-hydroxybenzophenones and alkyl malonate in the presence of DBU. The onepot synthesis is carried out with Knoevenagel condensation, intramolecular lactonization, and decarboxylation reactions. The method can be applied to a broad scope of neoflavonoids.
