39171-57-8Relevant academic research and scientific papers
Methylarene-based PAH synthesis via domino cyclization of 1, 1-difluoro-1-alkenes
Fuchibe, Kohei,Takao, Go,Takahashi, Hiroki,Ijima, Shiori,Ichikawa, Junji
, p. 2019 - 2029 (2019/12/23)
Polycyclic aromatic hydrocarbons (PAHs) containing 4-7 benzene rings were synthesized via a methylarene-based protocol. Trimethyl[2-(trifluoromethyl)allyl]silane was electrophilically benzylated with Ar1CH2Br (prepared from Ar1CH3) to afford 2-trifluoromethyl-1-alkenes that were in turn nucleophilically benzylated with Ar2CH2Li (prepared from Ar2CH3) through an SN2-type reaction to produce 1, 1-difluoroethylenes, which are cyclization precursors bearing two 2-arylethyl groups. Magic acid efficiently promoted the domino FriedelCrafts-type cyclization of these precursors, followed by dehydrogenation that enabled the connection among two aryl groups (Ar1 and Ar2) by forming two benzene rings between them, facilitating the synthesis of the desired higher-order PAHs. With the proposed protocol, the combination of even a limited number of methylarenes can yield a variety of PAHs in diverse configurations.
Effect of Spectral Shifts on the Resolution of trans-1-(2-Naphthyl)-2-phenylethene Conformer UV Spectra Based on Principal Component Analysis with Self-Modeling
Saltiel, Jack,Choi, Jong-Oh,Sears, Donald F. Jr.,Eaker, David W.,Mallory, Frank B.,Mallory, Clelia W.
, p. 13162 - 13170 (2007/10/02)
Application of principal component analysis with self-modeling (PCA-SM) to a matrix consisting of UV absorption spectra of trans-1-(2-naphthyl)-2-phenylethene (NPE) at different temperatures leads to two resolved pure component spectra.The significance of this resolution is evaluated by examining the spectra of three conformationally restricted NPE analogues: trans-1--2-phenylethene (1-MPE), trans-1--2-phenylethene (3-MPE), and trans-3-styrylidenebenzindane (BPE).It is established that temperature effects on the UV spectra of NPE reflect primarily the temperature dependence of the individual conformer spectra rather than any changes in conformer composition.Pure component UV absorption spectra generated by PCA-SM on the spectrothermal matrix of NPE UV spectra bear no resemblance to either the analogue spectra or the known NPE conformer spectra.PCA-SM treatment of a simulated spectral matrix shows that spectral shifts are reflected predictably in the appearance of the second eigenvector.The implications of our findings on results obtained from other PCA-SM spectral resolutions of spectrothermal matrices are discussed.
Photobromination of Side-Chain Methyl Groups on Arenes with N-Bromosuccinimide - Convenient and Selective Syntheses of Bis(bromomethyl)- and (Bromomethyl)methylarenes -
Futamura, Shigeru,Zong, Zhi-Min
, p. 345 - 348 (2007/10/02)
Photobromination of side-chain methyl groups on arenes with N-bromosuccinimide (NBS) was investigated.Visible light irradiation in benzene solvent was extremely effective in increasing the selectivity of the reaction and the efficiency for product purification.The photobromination of 1,4-, 1,8, 2,3-, and 2,6-dimethylnaphthalenes, 4,4'-dimethylbiphenyl, and p-xylene with 2.2 mol equivalents of NBS quantitatively afforded the corresponding bis(bromomethyl)arenes, respectively.The (bromomethyl)methylarenes were also obtained in good yields in the photobromination reactions of the above dimethylarenes with 1.1 mol equivalents of NBS.
Novel naphthalenyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents
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, (2008/06/13)
This invention relates to novel substituted 3H-1,2,3,5-oxathiadiazole 2-oxides, processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
Principal Component-Three Component Self-Modeling Analysis Applied to trans-1,2-Di(2-naphthyl)ethene Fluorescence
Sun, Ya-Ping,Sears, Donald F.,Saltiel, Jack,Mallory, Frank B.,Mallory, Clelia W.,Buser, Carolyn A.
, p. 6974 - 6984 (2007/10/02)
Fluorescence spectra of trans-1,2-di(2-naphthyl)ethene, DNE, obtained under varying conditions of excitation wavelength and oxygen and carbon tetrachloride concentrations in methylcyclohexane were resolved into three distinct components by application of principal component analysis combined with a three-component self-modeling technique.Spectral matrices for O2 and CCl4 quenching, treated separately, yielded nearly identical pure component fluorescence spectra.The spectra were assigned to each of the three conformers of DNE by comparison with spectra of 3-methyl derivatives.Stern-Volmer quenching plots for the individual conformers were shown to be independent of excitation wavelength, indicating that each conformer has a single lifetime.
