31554-16-2Relevant articles and documents
Diastereoselective Synthesis of CF3-Substituted Spiroisochromans by [1,5]-Hydride Shift/Cyclization/Intramolecular Friedel-Crafts Reaction Sequence
Tamura, Risa,Kitamura, Eriko,Tsutsumi, Ryosuke,Yamanaka, Masahiro,Akiyama, Takahiko,Mori, Keiji
, p. 2383 - 2387 (2019/03/29)
Developed herein is a diastereoselective synthesis of CF3-substituted spiroisochromans via C(sp3)-H bond functionalization involving sequential transformations ([1,5]-hydride shift/cyclization/elimination of MeOH/intramolecular Friedel-Crafts reaction).
Rearrangement-cleavage of ammonium salts containing a 3-methyl-2- naphthylmethyl group
Oganesyan,Grigoryan,Babayan,Kocharyan
, p. 951 - 956 (2007/10/03)
The example of the rearrangement-cleavage under the action of 25% aqueous potassium hydroxide at 90-92°C of ammonium salts containing both 3-methyl-2-naphthylmethyl and 2-bromoethyl, allyl, methallyl, 2-bromoallyl, 3-phenylallyl, 2-propynyl, or 3-phenylphenyl-2-propynyl groups was used to show that the reaction always involves the aromatic ring of the 3-methyl-2- naphthylmethyl group. Along with rearrangement-cleavage, nucleophilic substitution of the 2-naphthylmethyl group takes place.
SPIROINDANE OPIATE ANALOGS
-
, (2008/06/13)
The present invention provides biologically active compounds of the formulas (I) and (II): (* CHEMICAL STRUCTURE *) (I) (* CHEMICAL STRUCTURE *) (II) wherein R3 is H or a hydroxyl protecting group, R2 is OH, H or a protected hydroxyl group, R1 is alkyl, c
