17893-94-6Relevant academic research and scientific papers
Principal Component-Three Component Self-Modeling Analysis Applied to trans-1,2-Di(2-naphthyl)ethene Fluorescence
Sun, Ya-Ping,Sears, Donald F.,Saltiel, Jack,Mallory, Frank B.,Mallory, Clelia W.,Buser, Carolyn A.
, p. 6974 - 6984 (1988)
Fluorescence spectra of trans-1,2-di(2-naphthyl)ethene, DNE, obtained under varying conditions of excitation wavelength and oxygen and carbon tetrachloride concentrations in methylcyclohexane were resolved into three distinct components by application of principal component analysis combined with a three-component self-modeling technique.Spectral matrices for O2 and CCl4 quenching, treated separately, yielded nearly identical pure component fluorescence spectra.The spectra were assigned to each of the three conformers of DNE by comparison with spectra of 3-methyl derivatives.Stern-Volmer quenching plots for the individual conformers were shown to be independent of excitation wavelength, indicating that each conformer has a single lifetime.
Synthesis of Polycyclic Aromatic Hydrocarbons (PAHs) via a Transient Directing Group
Tang, Ming,Yu, Qinqin,Wang, Ziqi,Zhang, Chen,Sun, Bing,Yi, Ying,Zhang, Fang-Lin
, p. 7620 - 7623 (2018)
In this work, an efficient synthetic route was developed to construct PAHs with diverse shape, width, and edge topology. The precursors of PAHs were obtained by using a direct arylation of arenes via a transient ligand-directed C-H functionalization strategy and the cycloaromatization was readily achieved by using a Br?nsted acid catalyst. This novel route provides an opportunity to build up PAHs in a highly efficient manner.
PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS
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Page/Page column 95, (2018/12/13)
The present invention relates to pyrimidine derivatives of formula (I) wherein (R1)n, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
Herbicidal cyclohexane-1,3-dione derivatives
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, (2008/06/13)
Compounds of the formula STR1 wherein: R5 is a bicyclic aryl or nitrogen-containing heteroaryl ring system such as naphthyl, quinolyl, isoquinolyl or tetrahydroisoquinolyl, optionally substituted by a wide variety of groups; R4 and R
PREPARATION OF NAPHTHALDEHYDES BY CERIUM(IV)AMMONIUM NITRATE OXIDATION OF METHYLNAPHTHALENES.
Sydnes, Leiv K.,Burkow, Ivan C.,Hansen, Sissel H.
, p. 5703 - 5706 (2007/10/02)
Naphthalenes with an Me group in the 1-position gave aldehydes in good to excellent yields when oxidized with cerium(IV) ammonium nitrate (CAN) in 50percent HOAc at 85 deg C.Under the same conditions methylnaphthalenes with no Me group in a peri position gave aldehydes in fair yields but also significant amounts of 1,4-naphthoquinone.
Ortho Metalation Directed by α-Amino Alkoxides
Comins, Daniel L.,Brown, Jack D.
, p. 1078 - 1083 (2007/10/02)
The addition of aromatic aldehydes to certain lithium dialkylamides in benzene or tetrahydrofuran gave α-amino alkoxides which were ortho lithiated with excess n-butyllithium.Subsequent alkylation and hydrolysis provided ortho-substituted aromatic aldehydes via a one-pot reaction.The ortho metalation of α-amino alkoxides derived from 1- and 2-naphthaldehyde and various substituted benzaldehydes was examined.When N,N,N'-trimethylethylenediamine was used as the amine component of the α-amino alkoxide, metalation could be carried out at lower temperatures.This rate increase is due to an intramolecular TMEDA-like assisted metalation.The synthetic utility of this ortho metalation, including how varying the amine component of the α-amino alkoxide affects the regiochemistry and metalation rate, is discussed.
PHOTOOXYGENATIONS PAR TRANSFERT D'ELECTRON SENSIBILISEES PAR LE DICYANO-9,10 ANTHRACENE. ROLE DU SOLVANT ET FORMATION D'OXYGENE SINGULET.
Santamaria, J.,Gabillet, P.,Bokobza, L.
, p. 2139 - 2142 (2007/10/02)
Photooxygenation of naphtalenic compounds sensitized by electron acceptors like 9,10 dicyanoanthracene (DCA) is shown to proceed by two distinct ways depending on the solvent polarity.In a polar solvent superoxide ion (O2-.) as well as singlet oxygen (1O2*) are involved while in a non polar solvent only singlet oxygen is produced.
A ONE-POT ORTHO ALKYLATION OF AROMATIC ALDEHYDES
Comins, Daniel L.,Brown, Jack D.,Mantlo, Nathan B.
, p. 3979 - 3982 (2007/10/02)
The addition of aromatic aldehydes to lithium N-methylpiperazide in benzene gave α-amino alkoxides which were ortho-lithiated with excess n-butyllithium.Subsequent alkylation and hydrolysis provided ortho-substituted aromatic aldehydes via a one-pot reaction.
