391906-13-1Relevant articles and documents
2,4-Thiazolidinediones as potent and selective human β3 agonists
Hu, Baihua,Ellingboe, John,Gunawan, Iwan,Han, Stella,Largis, Elwood,Li, Zenan,Malamas, Michael,Mulvey, Ruth,Oliphant, Alexander,Sum, Fuk-Wah,Tillett, Jeff,Wong, Victoria
, p. 757 - 760 (2007/10/03)
Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC50 = 0.01 μM, IA = 1.19) and selective (more than 110-fold over β1 and β2 agonist activity) β3 agonist. This compound has also been proven to be active and selective in an in vivo mode.