391906-07-3Relevant academic research and scientific papers
SALT OF A PYRIDYL ETHANOLAMINE DERIVATIVE AND ITS USE AS A BETA-3-ADRENERGIC RECEPTOR AGONIST
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Page/Page column 19-20, (2008/06/13)
The present invention provides the tosylate salt of (R)-2-(2-(4-oxazol-4-yl-phenoxy)-ethylamino)-1-pyridin-3-yl-ethanol, the monohydrate of such salt, processes useful in the preparation of such salt and such monohydrate, pharmaceutical compositions compr
Azolidines as beta-3 adrenergic receptor agonists
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, (2008/06/13)
This invention provides compounds of Formula I having the structure wherein, A, X, Y, Z, W, R1, R2, R3, R4, R5, and R6 are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.
2,4-Thiazolidinediones as potent and selective human β3 agonists
Hu, Baihua,Ellingboe, John,Gunawan, Iwan,Han, Stella,Largis, Elwood,Li, Zenan,Malamas, Michael,Mulvey, Ruth,Oliphant, Alexander,Sum, Fuk-Wah,Tillett, Jeff,Wong, Victoria
, p. 757 - 760 (2007/10/03)
Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC50 = 0.01 μM, IA = 1.19) and selective (more than 110-fold over β1 and β2 agonist activity) β3 agonist. This compound has also been proven to be active and selective in an in vivo mode.
