39199-11-6

Upstream product

• 1123-25-7 1-methyl-1-cyclohexanecarboxylic acid 
• 2890-61-1 1-methyl-1-cyclohexancarboxylic acid chloride 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 83391-73-5 1-chloro-2-(1'-methylcyclohexyl)-2-phenoxyethylene 

Downstream Products

• 39199-31-0 1-(Methylthioacetyl)-1-methylcyclohexane 
• 39184-50-4 1-methylcarbamyloximino-1-(1-methylcyclohexyl)-2-methylthioethane 
• 1037835-11-2 1-{1-[2-(1-methylcyclohexyl)-2-oxoethyl]piperidin-4-yl}-5-(methylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-one 
• 1037834-31-3 6-fluoro-N-methyl-1-{1-[2-(1-methylcyclohexyl)-2-oxoethyl]piperidin-4-yl}-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxamide 
• 1350755-32-6 5-[2-(1-methylcyclohexyl)oxiran-2-yl]-1,3-thiazole 

Relevant academic research and scientific papers

INHIBITORS OF SERINE PALMITOYLTRANSFERASE

This invention provides compounds of the formula (I) useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred to as Syndrome X), impaired glucose tolerance, Cushing's disease, cardiovascular disease, prothrombotic conditions, myocardial infarction, hypertension, congestive heart failure, cardiomyopathy, atherosclerosis, dyslipidemia, sepsis, liver damage, retinal degenerative disorders, cachexia, emphysema, hepatitis C infections, HIV infections and inflammatory disorders and useful in methods for raising HDL plasma levels in a mammal. The compounds of this invention can also be used to prevent damage or loss of pancreatic islet beta cells (such as in the case of pancreatic beta cell apoptosis, including those related to insulin-dependent diabetes mellitus).

Preparation of monochloromethyl ketones

A process for the production of a monochloromethyl ketone of the formula STR1 in which R1, R2 and R3 each independently is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkinyl or aryl radical, or R1 and R2 together with the carbon atom to which they are attached form an optionally substituted carbocyclic ring, comprising reacting a 1,1-dichloroalkene of the formula STR2 with a phenolate of the formula STR3 in which R4 each independently is a halogen atom, a nitro group, or an optionally substituted alkyl, alkoxy or aryl radical, n is 0, 1, 2 or 3, and M is one equivalent of an alkali metal ion or alkaline earth metal ion, thereby to obtain a phenyl ether intermediate, and then subjecting the phenyl ether intermediate to an acid hydrolysis. The products are useful as intermediates in the synthesis of fungicides.