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1,3,5-Trifluoro-2,4-dinitrobenzene is an organic compound characterized by the presence of three fluorine atoms at the 1st, 3rd, and 5th carbon positions, and two nitro groups at the 2nd and 4th carbon positions on a benzene ring. This molecule is known for its high reactivity and stability, making it a valuable intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Due to its electron-withdrawing fluorine and nitro groups, it exhibits unique chemical properties, such as increased reactivity towards nucleophiles and a heightened sensitivity to electrophilic substitution reactions. The compound's structure and properties make it a versatile building block in the development of new materials and compounds with potential applications in various industries.

392-51-8

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392-51-8 Usage

Appearance

Yellow crystalline solid

Usage

a. Reagent in organic synthesis
b. Preparation of amines and nitrogen-containing compounds
c. Manufacture of dyes and pharmaceuticals

Chemical properties

a. Strong electrophile
b. Formation of carbon-carbon and carbon-nitrogen bonds

Toxicity

Toxic

Health hazards

a. Irritation to skin
b. Irritation to eyes
c. Irritation to respiratory system

Safety precautions

Avoid exposure

Check Digit Verification of cas no

The CAS Registry Mumber 392-51-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,9 and 2 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 392-51:
(5*3)+(4*9)+(3*2)+(2*5)+(1*1)=68
68 % 10 = 8
So 392-51-8 is a valid CAS Registry Number.

392-51-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,3,5-trifluoro-2,4-dinitrobenzene

1.2 Other means of identification

Product number -
Other names 2,4,6-trfluoro-1,3-dinitrobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:392-51-8 SDS

392-51-8Relevant academic research and scientific papers

Synthesis and 1-oxide/3-oxide interconversion of 4-substituted benzodifuroxans: A thorough NMR and theoretical study of the structure of 4-fluoro- and 4-chloro-benzodifuroxan

Jovené, Cyril,Jacquet, Morgane,Chugunova, Elena A.,Kharlamov, Sergey V.,Goumont, Régis

, p. 2057 - 2063 (2016)

The synthesis of the new 4-fluorobenzodifuroxan has been performed in one step from 2,4,6-trifluoro-1,3-dinitrobenzene implying a safe synthesis. Importantly, due to the 1-oxide/3-oxide interconversion, NMR spectra have shown that this compound exists as

Synthesis and Characterization of Fluorodinitrobenzenes with Tunable Melting Point: Potential Low Sensitive Energetic Plasticizer and Melt-Cast Carrier?

Li, Yunlu,Chen, Peng,Liu, Yan,Yin, Ping,He, Chunlin,Pang, Siping

, p. 1619 - 1624 (2020/10/12)

In order to explore the effects of fluoro substituents on the energy and safety of energetic compounds, a series of fluorodinitrobenzenes including 1,3-difluoro-2,4-dinitrobenzene (1), 1,5-difluoro-2,4-dinitrobenzene (2), 1,2,3-trifluoro-4,6-dinitrobenzne (3) and 1,3,5-trifluoro-2,4-dinitrobenzene (4) were prepared. All the compounds were fully characterized. The structures of 2 and 3 were further confirmed by single crystal X-ray diffraction analysis. The results show that these compounds exhibit comparable detonation properties (D = 6703-6978 m·s–1, and p = 21.3—23.7 GPa) to those of 2,4,6-trinitrotoluene (TNT) due to the significantly increased density of fluorine introduced. Low sensitivity (IS > 40 J, and FS > 360 N) of these compounds along with different melting points make them potential candidates for different allocation. Among them, 1 and 4 with the melting point of 42.5 °C and 55.2 °C, respectively, show promise for application in the field of energetic plasticizer. Compounds 2 and 3 are potential low sensitive melt-cast carrier due to their similar melting point and superior detonation performance to that of TNT.

Orthohalogen substituents dramatically enhance hydrogen bonding of aromatic ureas in solution

Giannicchi, Ilaria,Jouvelet, Benjamin,Isare, Benjamin,Linares, Mathieu,Dalla Cort, Antonella,Bouteiller, Laurent

supporting information, p. 611 - 613 (2014/01/06)

The phenylurea moiety is a ubiquitous synthon in supramolecular chemistry. Here we report that the introduction of chlorine or bromine atoms in the ortho positions to the urea unit is a simple and very efficient way to improve its intermolecular hydrogen bond (HB) donor character. This effect was demonstrated in solution both in the context of self-association of bis-ureas and hydrogen bonding of mono-ureas to strong HB acceptors. The Royal Society of Chemistry 2014.

Nitration of Strongly Deactivated Aromatics with Superacidic Mixed Nitric-Triflatoboric Acid (HNO3/2CF3SO3H-B(O3SCF3)3)

Olah, George A.,Orlinkov, Alexander,Oxyzoglou, Alexandros B.,Prakash, G. k. Surya

, p. 7348 - 7350 (2007/10/03)

The nitration of various deactivated arenes (including methanesulfonyl-, nitro-, and polyhalobenzenes) was carried out in good yield with mixed nitric-triflatoboric superacid.For example pentafluorobenzene gave pentafluoronitrobenzene in 99percent yield, nitrobenzene to m-dinitrobenzene in 92percent selectivity with 85percent overall yield, and methyl phenyl sulfone gave only the m-nitro isomer in 78percent isolated yield.Thus the new nitrating system gives high regioselectivity and yields under generally mild reaction conditions.The reagent system is compatible with many functional groups of arenes.

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