3920-12-5

Usage

Uses

Used in Pharmaceutical Industry:
1-amino-3-chloropropan-2-ol is used as an intermediate in the synthesis of chiral drugs for its unique chemical properties, facilitating the production of essential medications.
Used in Agrichemical Industry:
1-amino-3-chloropropan-2-ol is used as an intermediate in the synthesis of synthetic pesticides, such as propachlor, contributing to the development of effective agricultural chemicals.
Used in Surfactant and Detergent Production:
1-amino-3-chloropropan-2-ol is used as a key component in the manufacturing of surfactants and detergents, enhancing their cleaning and emulsifying properties.

InChI:InChI=1/C3H8ClNO/c4-1-3(6)2-5/h3,6H,1-2,5H2

Upstream product

• 141-97-9 ethyl acetoacetate 
• 106-89-8 epichlorohydrin 
• 19667-37-9 2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione 
• 6937-15-1 3-benzylidenamino-1-chloropropan-2-ol 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 51275-91-3 1-azido-3-chloro-propan-2-ol 
• 3920-13-6 1-chloro-3-(5-chloromethyl-4,5-dihydro-oxazol-2-ylamino)-propan-2-ol 

Downstream Products

• 50411-39-7 1-amino-3-(dimethylamino)propan-(2RS)-2-ol 

Relevant academic research and scientific papers

Synthesis of amine functionalized cellulose nanocrystals: Optimization and characterization

A simple protocol was used to prepare amine functionalized cellulose nanocrystals (CNC-NH2). In the first step, epichlorohydrin (EPH) was reacted with ammonium hydroxide to produce 2-hydroxy-3-chloro propylamine (HCPA). In the next step, HCPA was grafted to CNC using the etherification reaction in an organic solution media. Various reaction parameters, such as time, temperature, and reactant molar ratio were performed to determine the optimal reaction conditions. The final product (CNC-NH2(T)) was dialyzed for a week. Further purification via centrifugation yielded the sediment (CNC-NH2(P)) and supernatant (POLY-NH2). The presence of amine groups on the surface of modified CNC was confirmed by FTIR and the amine content was determined by potentiometric titration and elemental analysis. A high amine content of 2.2 and 0.6 mmol amine/g was achieved for CNC-NH2(T) and CNC-NH2(P), respectively. Zeta potential measurements confirmed the charge reversal of amine CNC from positive to negative when the pH was increased from 3 to 10. The flocculation of amine functionalized CNC due to its interactions with a negatively charged surfactant namely, sodium dodecyl sulfate (SDS) was investigated at pH 4. It showed promising results for applications, such as in flocculation of fine dispersions in water treatment. This simple and versatile synthetic method to produce high amine content CNC can be used for further conjugation as required for various applications.

An efficient chemoselective production of amines from azides using AlCl3/NaBH4

A practical reagent system AlCl3/NaBH4 is used for the preparation of amines from azides under mild reaction condition, in excellent yields.

A novel, chemoselective and efficient production of amines from azides using ZrCl4/NaBH4

A practical and cheaper reagent system ZrCl4/NaBH4 is used for the production of amines from azides is described.

A novel and efficient production of amines from azides using LiCl/NaBH4

A practical and efficient reagent system LiCl/NaBH4 is used for the production of amines from azides is described.