39206-86-5Relevant academic research and scientific papers
Conversion of 3-aryl-5-phenyl-2(3H)-furanones into 3(2H)-isothiazolone derivatives
Derbala, Hamed A.,Hamad, Abdel-Sattar S.,El Said, Waleed A.,Hashem, Ahmed I.
, p. 153 - 162 (2001)
Upon heating 3-aryl-5-phenyl-2(3H)-furanones (1a-C) with benzylamine at 100°C in the absence of solvents, ring opening occurred with the formation of the corresponding N-benzylamides (3a-c). When the latter compounds (3a-c) were allowed to react with thionyl chloride at room temperature, lhe corresponding isothiazolones (4a-c) were obtained. Treatment of the isothiazolones (4a-c) with sodium hydroxide in benzene at room temperature affected debenzoylation to give the corresponding 2-benzyl-4-aryl-3(2H)-isothiazolones (5a-c).
