Conversion of 3-aryl-5-phenyl-2(3H)-furanones into 3(2H)-isothiazolone derivatives

Article abstract of DOI:10.1080/10426500108040263

Upon heating 3-aryl-5-phenyl-2(3H)-furanones (1a-C) with benzylamine at 100°C in the absence of solvents, ring opening occurred with the formation of the corresponding N-benzylamides (3a-c). When the latter compounds (3a-c) were allowed to react with thionyl chloride at room temperature, lhe corresponding isothiazolones (4a-c) were obtained. Treatment of the isothiazolones (4a-c) with sodium hydroxide in benzene at room temperature affected debenzoylation to give the corresponding 2-benzyl-4-aryl-3(2H)-isothiazolones (5a-c).

Full text of DOI:10.1080/10426500108040263

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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CONVERSION OF 3-ARYL-5-
PHENYL-2(3H)-FURANONES
INTO 3(2H)-ISOTHIAZOLONE
DERIVATIVES
Hamed A. Derbala a , Abdel-Saitar S. Hamad a ,
Waleed A. El Said a & Ahmed I. Hashem a
a Chemistry Dept., Faculty of Science , Ain Shams
University , Abbassia, Cairo, Egypt
Published online: 04 Oct 2006.
To cite this article: Hamed A. Derbala , Abdel-Saitar S. Hamad , Waleed A. El Said &
Ahmed I. Hashem (2001) CONVERSION OF 3-ARYL-5-PHENYL-2(3H)-FURANONES INTO
3(2H)-ISOTHIAZOLONE DERIVATIVES, Phosphorus, Sulfur, and Silicon and the Related
Elements, 175:1, 153-162, DOI: 10.1080/10426500108040263
To link to this article: http://dx.doi.org/10.1080/10426500108040263
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