39255-24-8

Basic information

• Product Name: BEB
• Synonyms: BEB;1-Bromo-4-(2-butoxyethoxy)benzene
• CAS NO: 39255-24-8
• Molecular Formula: C₁₂H₁₇BrO₂
• Molecular Weight: 273.16618
• Mol File: 39255-24-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 324.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• CAS DataBase Reference: BEB(CAS DataBase Reference)
• NIST Chemistry Reference: BEB(39255-24-8)
• EPA Substance Registry System: BEB(39255-24-8)

Safety Data

• Hazardous Substances Data: 39255-24-8(Hazardous Substances Data)

Usage

General Description

1-Bromo-4-(2-butoxyethoxy)benzene, also known as 1-Bromo-4-(2-butoxyethoxy)benzene, is a chemical compound with the molecular formula C10H15BrO2. It is a brominated aromatic compound with a butoxyethoxy group attached to the benzene ring. This chemical is used in the synthesis of other organic compounds and can also be used as a building block in various reactions. It is important to handle this chemical with care, as it is classified as hazardous and can cause skin and eye irritation. Additionally, it should be stored and disposed of properly to avoid any potential environmental hazards.

Upstream product

• 109-65-9 1-bromo-butane 
• 34743-88-9 2-(4-bromophenoxy)ethanol 
• 122-99-6 2-Phenoxyethanol 
• 542-69-8 1-iodo-butane 
• 106-41-2 4-bromo-phenol 
• 10503-96-5 1-(2-chloroethoxy)butane 

Downstream Products

• 313738-96-4 7-{4-[2-(butoxy)ethoxy]phenyl}-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 
• 497223-28-6 (S)-8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-(((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide methanesulfonate 
• 313740-83-9 7-{4-[2-(butoxy)ethoxy]phenyl}-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxamide 
• 313729-60-1 7-{4-[2-(butoxy)ethoxy]phenyl}-1-cyclohexylmethyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 
• 313729-55-4 methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-cyclohexylmethyl-2,3-dihydro-1H-1-benzazepine-4-carboxylate 
• 719297-15-1 methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-imidazol-2-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate 
• 719297-16-2 methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate 
• 313753-40-1 methyl 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-5-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate 
• 313752-00-0 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-5-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 
• 313751-95-0 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 
• 313751-84-7 7-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-imidazol-2-yl)methyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 
• 313729-92-9 7-{4-[2-(butoxy)ethoxy]phenyl}-1-cyclobutylmethyl-2,3-dihydro-1H-1-benzazepine-4-carboxylic acid 

Relevant articles and documents

Practical synthesis of an orally active CCR5 antagonist, 7-{4-[2-(Butoxy)-ethoxy]phenyl}-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino] methyl}phenyl)-1-propyl-2,3-dihydro-1H-1-benzazepine-4-carboxamide

A practical method of synthesizing 7-{4-[2-(butoxy)ethoxy]-phenyl}-N-(4- {[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}-phenyl)-1-propyl-2, 3-dihydro-1H-1-benzazepine-4-carboxamide (8), an orally active CCR5 antagonist, has been developed. Methyl 7-bromo-1-propyl-2,3-dihydro-1H-1-benzazepine-4- caboxylate (14a) was synthesized in good yield by the esterification of 4-[(4-bromo-2-formylphenyl)(propyl)amino]butanoic acid (13) followed by an intramolecular Claisen type reaction with 28% sodium methoxide in dimethyl carbonate as a solvent in one pot. The Suzuki-Miyaura reaction of 14a and 1-bromo-4-(2-butoxyethoxy)benzene (10) followed by hydrolysis and amidation gave 8. A new inexpensive method without chromatographic purification was established.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: ?wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5and R6are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5and R6may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof , which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.