34743-88-9

Usage

Uses

2-(4-Bromophenoxy)ethanol was used in the synthesis of lithium 2-(4-lithiophenoxy)ethoxide.

InChI:InChI=1/C8H9BrO2/c9-7-1-3-8(4-2-7)11-6-5-10/h1-4,10H,5-6H2

Upstream product

• 106-41-2 4-bromo-phenol 
• 107-07-3 2-chloro-ethanol 
• 7003-65-8 sodium 4-bromophenoxide 
• 122-99-6 2-Phenoxyethanol 
• 540-51-2 2-bromoethanol 
• 96-49-1 [1,3]-dioxolan-2-one 
• 134671-56-0 2-(4-bromophenoxy)acetaldehyde 

Downstream Products

• 66826-78-6 5-bromo-2,3-dihydrobenzo[b]furan 
• 113202-49-6 trimethylsilyl 2-(4-bromophenoxy)ethyl ether 
• 55162-34-0 1-bromo-4-(2-chloroethoxy)benzene 
• 62644-06-8 β-p-Bromphenoxyaethyl-m-tolylcarbamat 
• 62643-95-2 β-p-Bromphenoxyaethyl-o-tolylcarbamat 
• 179031-78-8 1-(2-(2-methoxymethoxy)ethoxy)-4-bromobenzene 
• 1711-24-6 4-(2-hydroxyethoxy)benzoic acid 
• 864067-05-0 5-bromo-2-[2-(4-bromo-phenoxy)-ethoxy]-pyridine 
• 279262-45-2 {4-[2-(pentyloxy)ethoxy]phenyl}boronic acid 
• 333382-90-4 2,6-bis-[2-(4-vinyl-phenoxy)-ethoxymethyl]-pyridine 
• 279262-26-9 1-bromo-4-(2-propoxyethoxy)benzene 
• 133305-43-8 [2-(4-Bromophenoxy)ethoxy](1,1-dimethylethyl)dimethylsilane 

Relevant academic research and scientific papers

Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C-H Amination

We report both an intermolecular C-H amination of arenes to access N-methylanilines and an intramolecular variant for the synthesis of tetrahydroquinolines. A newly developed, highly electrophilic aminating reagent was key for the direct synthesis of unprotected N-methylanilines from simple arenes. The reactions display a broad functional group tolerance and employ catalytic amounts of a benign iron salt under mild reaction conditions.

BENZOTHIOPHENE ESTROGEN RECEPTOR MODULATORS

This invention is a benzothiophene estrogen receptor modulator or its pharmaceutically acceptable salt or a pharmaceutically acceptable composition thereof to treat an estrogen-related medical disorder.

PD-1/PD-L1 INHIBITORS

Compounds according to formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

Synthesis and antibacterial activity of 3-benzylamide derivatives as FtsZ inhibitors

The emergence and spread of multidrug-resistant strains of the human pathological bacteria are generating a threat to public health worldwide. In the current study, a series of PC190723 derivatives was synthesized and investigated for their antimicrobial activity. The compounds exhibited good activity against several Gram-positive bacteria as determined by comparison of diameters of the zone of inhibition of test compounds and standard antibiotics. Compound 9 with a fluorine substitution on the phenyl ring showed the best antibacterial activity in the series against M. smegmatis with the zone ratio of 0.62, and against S. aureus with the zone ratio of 0.44. The results from this study indicate that based on the unique 3-methoxybenzamide pharmacophore, compound 9 may represent a promising lead candidate against Gram-positive bacteria that are worthy of further investigation

A robust and simple protocol for the synthesis of arylfluorophosphonates

Fluorophosphonates represent powerful probes for the identification and analysis of active serine hydrolases in activity based protein profiling. Although alkylphosphonofluoridates are widely used for such purposes, little is known about the synthesis and purification of arylphosphonofluoridates, which may be useful tools for screening enzyme activities toward aromatic esters. Our optimized route makes this subclass of transition state inhibitors broadly accessible for a diverse series of phosphonic acid derivatives using a combination of selective monoesterification with EDC·HCl and subsequent mild fluorination with DAST. All compounds were isolated as pure materials using a simple acid-base extraction protocol in 76-93% yields over two steps. These probes can be stored under an inert atmosphere at -24 °C for several months without significant degradation.

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold

Previously, we identified 1-(2-(4-bromophenoxy)ethoxy)-3-(4-(2- methoxyphenyl)piperazin-1-yl)propan-2-ol (1) as a novel Hsp90 inhibitor with moderate activity through virtual screening. In this study, we report the optimization process of 1. A series of analogues containing the 1-phenylpiperazine core scaffold were synthesized and evaluated. The structure-activity relationships (SAR) for these compounds was also discussed for further molecular design. This effort afforded the most active inhibitor 13f with improved activity in not only target-based level, but also cell-based level compared with the original hit 1.

The inhibition of monoamine oxidase by 8-(2-phenoxyethoxy)caffeine analogues

Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an IC 50 value of 0.383M towards MAO-B. In an attempt to improve on the inhibition potency of this compound and to discover highly potent reversible MAO-B inhibitors, in the present study, a series of 8-(2-phenoxyethoxy)caffeine analogues containing various substituents on C4 of the phenoxy ring, were synthesized and evaluated as inhibitors of human MAO-A and -B. The results show that the 8-(2-phenoxyethoxy)caffeine analogues are selective and reversible MAO-B inhibitors with the most potent homologue, 8-{2-[4-(trifluoromethyl) phenoxy]ethoxy}caffeine, exhibiting an IC50 value of 0.061μM. These highly potent inhibitors are useful leads in the design of therapies for neurodegenerative disorders such as Parkinsons disease. Georg Thieme Verlag KG Stuttgart New York.

Microwave mediated protection of hindered phenols and alcohols

Hindered phenols and alcohols were protected as their corresponding ethers using different alkylating agents in presence of KOH/DMSO under microwave irradiation.

Synthesis of new cores and their use in the preparation of polyester dendrimers

Six dendrimer and dendron cores terminated by hydroxyl groups that are neither phenolic nor cleavable by hydrogenolysis have been prepared in a consistent one-pot manner from terminal allyl groups by reduction of the product of reductive ozonolysis. Some of the terminal allyl derivatives are new and others have been prepared by new methods. The well-known O-benzylidene derivative of 2,2′-bis(hydroxymethyl)propanoic acid was shown to be the cis-stereoisomer. A new AB3-type anhydride, tris(benzyloxymethyl) acetic anhydride has been prepared. It was demonstrated that these cores and dendrons could be assembled into first and second generation homo- and mixed polyester dendrimers.

Photoinduced electron transfer in a fullerene-oligophenylenevinylene dyad

A dialkylamino-subtituted oligophenylenevinylene (OPV) derivative bearing a fullerene subunit (F-D) has been prepared. The electrochemical properties of F-D have been investigated by cyclic voltammetry. Whereas the first reduction is centered on the C60 unit, the oxidation is centered on the dialkylamino subunit of the OPV rod. In F-D, both the OPV and the fullerene-centered fluorescence bands are quenched and this suggests the presence of photoinduced electron transfer from the amino-substituted OPV to the carbon sphere. By means of bimolecular quenching experiments, transient absorption spectral fingerprints of the radical cationic species have been detected in the VIS (670 nm) and NIR (1300-1500 nm) regions, along with the much weaker fullerene anion band at λmax = 1030 nm. Intramolecular photoinduced electron transfer occurs in the investigated dyad and a relatively long-lived charge-separated state has been detected, with a lifetime of 135 and 85 ns in toluene and benzonitrile, respectively. The longer lifetime in the less polar solvent suggests a Marcus inverted region behavior for the charge recombination process.