39255-60-2

Basic information

• Product Name: N'-(4-BroMo-2-cyanophenyl)-N,N-diMethylforMiMidaMide
• Synonyms: N'-(4-BroMo-2-cyanophenyl)-N,N-diMethylforMiMidaMide;N'-(4-Bromo-2-cyanophenyl)-N,N-dimethylformamidine;N'-(4-Bromo-2-cyanophenyl)-N,N-dimethylformamidine
• CAS NO: 39255-60-2
• Molecular Formula: C₁₀H₁₀BrN₃
• Molecular Weight: 252.1105
• Mol File: 39255-60-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 61.0 to 65.0 °C
• Appearance: /
• CAS DataBase Reference: N'-(4-BroMo-2-cyanophenyl)-N,N-diMethylforMiMidaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(4-BroMo-2-cyanophenyl)-N,N-diMethylforMiMidaMide(39255-60-2)
• EPA Substance Registry System: N'-(4-BroMo-2-cyanophenyl)-N,N-diMethylforMiMidaMide(39255-60-2)

Safety Data

• Hazardous Substances Data: 39255-60-2(Hazardous Substances Data)

Usage

General Description

N'-(4-Bromo-2-cyanophenyl)-N,N-dimethylformamidamide is a chemical compound with the molecular formula C11H11BrN2O. It belongs to the class of formamidamides and is commonly used as a reagent in organic synthesis. N'-(4-BroMo-2-cyanophenyl)-N,N-diMethylforMiMidaMide is a colorless solid that is soluble in most organic solvents. It has applications in the pharmaceutical and agriculture industries, as well as in research laboratories for various synthetic processes. N'-(4-Bromo-2-cyanophenyl)-N,N-dimethylformamidamide is known for its role as a versatile building block in the creation of complex organic molecules and is valued for its high purity and stability.

Upstream product

• 39263-32-6 2-amino-5-bromobenzonitrile 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 231277-92-2 lapatanib 
• 944549-41-1 N-[3-chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-bromo-quinazolin-4-amine 

Relevant articles and documents

Lapatinib a novel process for the preparation of

The present invention provides a preparation method of lapatinib. The method comprises contacting a compound shown as a formula 1 with a compound shown as a formula 2 to produce a compound shown as a formula 3; reducing the compound shown as the formula 3 to produce a compound shown as a formula 4; contacting a compound shown as a formula 5 with N,N-dimethylformamide dimethyl acetal to produce a compound shown as a formula 6; contacting the compound shown as the formula 6 with the compound shown as the formula 4 to produce a compound shown as a formula 7; in the presence of an acid, an alkali and NaNH(OAc)3, contacting a compound shown as a formula 8 with a compound shown as a formula 9 to produce a compound shown as a formula 10; in the presence of a catalyst and an alkali, contacting the compound shown as the formula 10 with a compound shown as a formula 11 to produce a transition intermediate, and contacting the transition intermediate with the compound shown as the formula 7 and p-toluenesulfonic acid to produce a compound shown as a formula I; through use of the method, the lapatinib can be effectively prepared.

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