392686-83-8

Upstream product

• 71-23-8 propan-1-ol 
• 64-04-0 phenethylamine 
• 123-38-6 propionaldehyde 

Downstream Products

• 894086-16-9 2-ethyl-4-oxo-5-(2-oxo-octadecyl)-1-phenethyl-pyrrolidine-3-carboxylic acid methyl ester 
• 894086-31-8 2-ethyl-4-oxo-5-(2-oxo-tetradecyl)-1-phenethyl-pyrrolidine-3-carboxylic acid methyl ester 
• 27906-91-8 N-propyl-2-phenylethylamine 
• 7373-13-9 octadecan-2-one 

Relevant academic research and scientific papers

A synthetic approach to the plakoridines modeled on a biogenetic theory

An expedient synthetic route to the fully substituted pyrrolidine ring system of the plakoridines is described using an approach modeled on a plausible biosynthetic pathway.

Ruthenium-catalyzed N-alkylation of amines with alcohols under mild conditions using the borrowing hydrogen methodology

Using a simple amino amide ligand, ruthenium-catalyzed one-pot alkylation of primary and secondary amines with simple alcohols was carried out under a wide range of conditions. Using the alcohol as solvent, alkylation was achieved under mild conditions, even as low as room temperature. Reactions occurred with high conversion and selectivity in many cases. Reactions can also be carried out at high temperatures in organic solvent with high selectivity using stoichiometric amounts of the alcohol.

Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells

The synthesis of several 1-alkyl-1,2,3,4-tetrahydroisoquinolines, which may play an important role in Parkinson's disease, has been achieved by modified Pictet-Spengler cyclization of the formyliminium ion. The direct cytotoxicity and preventative effects

Chemical predisposition in synthesis: application to the preparation of the pyrrolidine natural products, plakoridines A and B

The pyrrolidine natural products, plakoridines A and B, as well as an array of unnatural analogues, have been prepared using a five-step synthetic sequence modelled on a biogenetic theory. The key transformation involves a 'Mannich/Michael/internal-redox'

Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase

An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT).

Preparation of benzolactams by Pd(OAC)2-catalyzed direct aromatic carbonylation

We developed a new method for Pd(II)-catalyzed direct aromatic carbonylation in a phosphine-free catalytic system using Pd(OAc)2 and Cu(OAc)2 in an atmosphere of CO gas containing air. The carbonylation proceeded with ortho-palladation, inducing a remarkable site selectivity to afford a variety of five- or six-membered benzolactams from secondary ω-arylalkylamines, such as N-alkylbenzylamines or N-alkylphenethylamines. Copyright

Synthesis of imines, diimines and macrocyclic diimines as possible ligands, in aqueous solution

Although it is recognized that the presence of water is disadvantageous for imine synthesis, we demonstrate that such synthesis can be effective in completely aqueous media, without any catalyst and under mild conditions. Thus, arylaryl, aryl-alkyl, alkyl-aryl and alkyl-alkyl monoimines as well as a large variety of diimines are obtained by direct condensation of the corresponding carbonyl compounds and amines, in water. The same process is used to synthesize macrocyclic diimines starting from methylene, ethylene, trimethylene and tetramethylene glycol bis(2-formylphenyl ether) and ethylene-, trimethylene- and tetramethylene-diamine, some of these macrocycles being known for their chelating properties.