709042-33-1Relevant academic research and scientific papers
Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase
Shaw, Antony N.,Tedesco, Rosanna,Bambal, Ramesh,Chai, Deping,Concha, Nestor O.,Darcy, Michael G.,Dhanak, Dashyant,Duffy, Kevin J.,Fitch, Duke M.,Gates, Adam,Johnston, Victor K.,Keenan, Richard M.,Lin-Goerke, Juili,Liu, Nannan,Sarisky, Robert T.,Wiggall, Kenneth J.,Zimmerman, Michael N.
, p. 4350 - 4353 (2009)
The synthesis and optimisation of HCV NS5B polymerase inhibitors with improved potency versus the existing compound 1 is described. Substitution in the benzothiadiazine portion of the molecule, furnishing improvement in potency in the high protein Replicon assay, is highlighted, culminating in the discovery of 12h, a highly potent oxyacetamide derivative.
