3948-84-3

Upstream product

• 622-63-9 ethyl p-tolyl sulfide 
• 623-13-2 4-methylphenyl methylsulfide 
• 14905-81-8 1-(isopropylthio)-4-methylbenzene 
• 106-45-6 para-thiocresol 

Relevant academic research and scientific papers

Direct synthesis of phosphorotrithioites and phosphorotrithioates from white phosphorus and thiols

White phosphorus (P4) is still the major commercial P-atom source for the production of organophosphorus compounds. Conventionally, C-S-P bonds were constructed from environmentally questionable P(O)X directly or indirectly. From the green chemistry point of view, formation of C-S-P bonds from inorganic molecule P4 in an easy-to-operate and atom-economical way is essential because it will avoid the hazardous chlorination process. Only five methods for the formation of C-S-P bonds from P4 have been developed over the past 70 years. Here, the first general and high-yielding synthesis of P(SR)3 and P(O)(SR)3 involving P4 and thiols is presented. With the use of KOH or K2CO3 as a base and DMSO-toluene as a solvent, both arythiols and alkylthiols are tolerant in this transformation. The reaction is characterized by a complete conversion of white phosphorus. This operationally simple and environmentally sound reaction shows a broad scope of substrates and good functional group tolerance. Moreover, this method can be easily adapted to large-scale preparation.

The Reaction of Alkyl-substituted Thioanisoles with PCl3 and AlCl3: a Route to Benzothiadiphospholobenzothiadiphosphole Derivatives

The synthesis of benzothiadiphospholobenzothiadiphosphole derivatives starting from alkyl-substituted thioanisoles and PCl3-AlCl3 is reported.The reaction is carried out at reflux in the absence of solvent and the yields are dependent on the starting sulphide.These new heterocycles can be purified by simple filtration on a Florisil column and have been characterized by 1H-, 13C-, (1H)31P-n.m.r. and mass spectroscopy analyses.New unexpected findings are also described.