14905-81-8

Basic information

• Product Name: Isopropyl 4-methylphenyl sulfide
• Synonyms: 1-Methyl-4-[(1-methylethyl)thio]benzene;Isopropyl 4-methylphenyl sulfide;Isopropyl p-tolyl sulfide;Isopropyl(4-methylphenyl) sulfide;1-methyl-4-propan-2-ylsulfanylbenzene
• CAS NO: 14905-81-8
• Molecular Formula: C₁₀H₁₄S
• Molecular Weight: 166.28
• Mol File: 14905-81-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 233.5°C at 760 mmHg
• Flash Point: 93.6°C
• Appearance: /
• Density: 0.97g/cm³
• Vapor Pressure: 0.085mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: Isopropyl 4-methylphenyl sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: Isopropyl 4-methylphenyl sulfide(14905-81-8)
• EPA Substance Registry System: Isopropyl 4-methylphenyl sulfide(14905-81-8)

Safety Data

• Hazardous Substances Data: 14905-81-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 4629, 1982 DOI: 10.1016/S0040-4039(00)85672-5

InChI:InChI=1/C10H14S/c1-8(2)11-10-6-4-9(3)5-7-10/h4-8H,1-3H3

Upstream product

• 75-29-6 isopropyl chloride 
• 106-45-6 para-thiocresol 
• 75-30-9 2-iodo-propane 
• 106-43-4 para-chlorotoluene 
• 20607-43-6 sodium isopropanethiolate 
• 624-31-7 4-tolyl iodide 
• 75-26-3 isopropyl bromide 
• 17041-81-5 p-tolyl benzenethiosulfonate 
• 1539-32-8 4-isopropyl-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 1517-74-4 1-(isopropylsulfinyl)-4-methylbenzene 
• 106-38-7 para-bromotoluene 
• 75-33-2 2-propanethiol 
• 106-46-7 para-dichlorobenzene 
• 106-53-6 para-bromobenzenethiol 

Downstream Products

• 1517-74-4 1-(isopropylsulfinyl)-4-methylbenzene 
• 50337-52-5 imino(isopropyl)(p-tolyl)-λ⁶-sulfanone 
• 1517-74-4 (+)-(R)-isopropyl p-tolyl sulfoxide 
• 20884-71-3 N,N-diethyl-p-(isopropylsulfonyl)-benzamide 
• 20884-79-1 N-[2-(3,4-Dimethoxy-phenyl)-aethyl]-p-isopropylsulfonyl-benzoesaeureamid 
• 20884-81-5 N-(3,4-Dichlor-phenyl)-p-isopropylsulfonyl-benzoesaeureamid 
• 20884-85-9 p-(isopropylsulfonyl)-benzoic acid, 2-isopropylhydrazide 
• 20884-97-3 p-Isopropylsulfonyl-benzoesaeure-ethylester 
• 20884-83-7 p-(Isopropylsulfonyl)-benzoesaeure-hydrazid 
• 74074-86-5 ethoxycarbonylmethyl 2-methyl-2-(p-tolylsulfonyl)propanedithioate 
• 74074-89-8 <2-(p-tolylsulfonyl)-2-propyl>(methylthio)sulfine 
• 74074-88-7 methyl 2-methyl-2-(p-tolylsulfonyl)propanedithioate 
• 51751-71-4 1-methyl-4-(propane-2-sulfonyl)benzene 
• 1517-74-4 (-)-(S)-isopropyl (4-tolyl) sulfoxide 

Relevant articles and documents

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Compounds of general formula (A) can be used for treating ATR kinase-mediated diseases, for example, hyperplastic diseases such as cancers. Also provided are a pharmaceutical composition of the compounds of general formula (A), a use of the pharmaceutical composition for treating the ATR kinase-mediated diseases and a preparation method for the pharmaceutical composition.

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Asymmetrical diaryl or aryl alkyl thioethers can be prepared in good to excellent yields by coupling the appropriate aryl iodides and aryl or alkyl bromines using acetyl thiourea as a thiolprecursor, Cu2O as a catalyst, KOH as a base, and PEG 400-H2O as a solvent under ligand-free conditions.