Halogenation of 1-trifluoromethyl enamines: A new and efficient synthesis of α-bromo-and α-iodo-trifluoromethyl ketones

Article abstract of DOI:10.1016/S0022-1139(96)03453-7

Treatment of the 1-trifluoromethyl enamines 1a-d with bromine or iodine results in the formation of the corresponding iminium salts. Treatment of any of these salts with methanol results in the formation of the corresponding α-halo-trifluoromethyl ketones