395099-48-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-fluorophenyl)-1H-indazol-5-amine is used as a building block for the synthesis of various organic compounds, particularly in the development of new drugs. Its unique structure and properties make it a promising candidate for the creation of novel therapeutic agents.
Used in Medicinal Chemistry Research:
3-(4-fluorophenyl)-1H-indazol-5-amine is used as a valuable tool in medicinal chemistry and drug discovery. Its potential pharmacological properties and therapeutic effects in the treatment of various diseases make it an important compound for further research and development.
Used in Drug Synthesis:
3-(4-fluorophenyl)-1H-indazol-5-amine is used in the synthesis of various organic compounds, contributing to the development of new drugs with potential therapeutic effects. Its unique structure allows for the creation of novel chemical entities with potential applications in the treatment of various diseases.

Upstream product

• 817200-27-4 C₁₃H₈FN₃O₂ 
• 478837-59-1 3-bromo-1H-indazol-5-amine 
• 1765-93-1 4-fluoroboronic acid 

Relevant academic research and scientific papers

Efficient synthesis of 3-aryl-1H-indazol-5-amine by Pd-catalyzed Suzuki-Miyaura cross-coupling reaction under microwave-assisted conditions

Various 3-aryl-1H-indazol-5-amine derivatives were synthesized by Pd-catalyzed Suzuki-Miyaura cross-coupling reaction of (NH) free 3-bromo-indazol-5-amine with arylboronic acids under microwave-assisted conditions. The coupling reaction can be carried out under the conditions with dioxane/H2O as solvent, Pd(OAc)2 and RuPhos as catalyst system, and K3PO4 as a base in good to excellent yields.

POLYCYCLIC INDAZOLE DERIVATIVES THAT ARE ERK INHIBITORS

Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

Indazole compounds, compositions thereof and methods of treatment therewith

This invention is generally directed to the use of Indazole Compounds for treating or preventing diseases associated with protein kinases, including tyrosine kinases, such as proliferative diseases, inflammatory diseases, abnormal angiogenesis and diseases related thereto, atherosclerosis, macular degeneration, diabetes, obesity, pain and others. The methods comprise the administration to a patient in need thereof of an effective amount of an indazole compound that inhibits, modulates or regulates tyrosine kinase signal transduction. Novel indazole compounds or pharmaceutically acceptable salt thereof are presented herein.

Methods for treating an inflammatory condition or inhibiting JNK

This invention is generally directed to Indazole Derivatives having the following structure: 1 or pharmaceutically acceptable salt thereof, wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of diseases and disorders that are responsive to JNK inhibition, such as an inflammatory disease or disorder. Thus, methods of treating such diseases and disorders are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

Indazole derivatives as JNK inhibitors and compositions and methods related thereto

Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.