39524-37-3Relevant academic research and scientific papers
An improved synthesis of α-AZA, α-AZP and α-AZG, the precursors to clinical markers of tissue hypoxia
Kumar, Piyush,Wiebe, Leonard I.,Atrazheva, Elena,Tandon, Manju
, p. 2077 - 2078 (2001)
α-[123I]-IAZA and α-[123I]-IAZP are experimental diagnostic radiopharmaceuticals which have been used clinically to diagnose hypoxia in a number of pathologies, including cancer, peripheral vascular disease, rheumatoid arthritis and brain trauma. These nitroimidazole nucleosides are synthesized from the non-iodinated nucleosides AZA, AZP and AZG, respectively. Earlier methods report low chemical yields for the synthesis of these precursors. The modified procedures now reported provide nearly quantitative yields of these compounds, thereby substantially reducing the cost and effort of synthesis.
A gelator-starch blend for dry powder based instant solidification of crude oil at room temperature
Pathak, Navendu P.,Rajkamal,Yadav, Somnath
supporting information, p. 2999 - 3002 (2020/03/18)
Immobilization of crude oil via solidification is a technique that allows for the control and remediation of oil spills. Gelation using supramolecular gelators is a powerful method for the solidification of crude oil. However, this method suffers from the limitation that the gelator has to be dispersed over the crude oil as a solution in environmentally harmful and volatile carrier solvents. Compared to this, the solid dispersal of the dry powder solidifier offers a very attractive solution to the problem but has rarely been reported with very limited success. Herein, we report a previously untested method for the dispersal of the solid gelator as a gelator-natural polymer blend that allows the uniform dispersion of the gelator over a wider bulk of the crude oil, resulting in its ultrafast gelation in less than 30 s at ambient temperature. Also, the technique is successful at low loadings of the composite material that contains the gelator at very low concentrations (0.34%, w/v).
Synthesis of enantiomerically pure enones (2-benzyloxypyran-3-ones)derived from pentoses
Dada, Lucas,Manzano, Verónica E.,Varela, Oscar
, p. 31 - 40 (2019/05/24)
The useful synthons sugar enones (2-benzyloxypyran-3-ones)derived from pentoses have been prepared starting from 2-acetoxyglycals or benzyl pentopyranosides. The glycals were glycosylated with benzyl alcohol in the presence of a Lewis acid (SnCl4/su
Arabinose based gelators: Rheological characterization of the gels and phase selective organogelation of crude-oil
Rajkamal,Pathak, Navendu Prakash,Chatterjee, Debnath,Paul, Abhijit,Yadav, Somnath
, p. 92225 - 92234 (2016/10/11)
Oil-spills, whether marine or terrestrial, result in major devastation to the environment and ecosystem, loss of habitat and damage to the economy. While inevitable in the current scenario, oil spillages necessitate prompt remedial action to limit the damage caused. A recent strategy towards this is to congeal the spilled oil into a gel through gelation (for terrestrial oil-spills) or through Phase Selective Organogelation (PSOG) for marine oil-spills which can stem the spread of the oil and also provide for the easy removal and reclamation of the gelled oil. Herein, we report two triazolylarabinoside derivatives that are stable, completely insoluble in water and can carry out the gelation as well as the PSOG of hydrocarbon based organic solvents, petrol, diesel and also crude-oil. The gels have been characterized thoroughly by optical microscopy, FESEM, AFM, XRD and rheological experiments. The gelation of crude-oil has also been unequivocally established via rheological studies. The easily synthesized and cheap triazolylarabinosides could provide simple gelators for the remediation of marine/terrestrial oil-spills.
Design and synthesis of DNA-intercalating 9-fluoren-β-O-glycosides as potential IFN-inducers, and antiviral and cytostatic agents
Alcaro,Arena,Neri,Ottana,Ortuso,Pavone,Vigorita
, p. 1781 - 1791 (2007/10/03)
Novel 9-fluoren-β-O-glycosides, designed as DNA-intercalating agents in structural correlation with antiviral tilorone and anticancer anthracyclines, have been prepared with yields in β-anomers ranging between 25 and 63%. They have been screened for antiproliferative, immunostimulating and antiviral properties against HSV-1 and HSV-2 viruses. Compounds displaying significant antiviral activity against HSV-2 are acetylated 1 and deprotected 6 9-fluorenyl-O-D-arabinopyranoses, whereas 9-fluorenyl-O-D-glucopyranose 3 is the most effective on HSV-1 replication, followed by 1 and 6. The conformational properties of these compounds have been evaluated by molecular modelling techniques.
A practical asymmetric synthesis of a pseudomonic acid precursor from D-arabinose or D-xylose
Balog, Aaron,Yu, Marvin S.,Curran, Dennis P.,Yu, Guixue,Carcanague, Daniel R.,Shue, Youe-Kong
, p. 935 - 944 (2007/10/03)
The asymmetric synthesis of multi-gram quantities of a pseudomonic acid precursor is described. Improvements on the literature synthesis of diacetyl arabinal from arabinose are also reported.
