3954-48-1

Usage

Derivative

Quinoline

Usage

Synthesis of various organic compounds

Pharmacological Properties

a. Antihypertensive activity
b. Antiarrhythmic activity

Potential Applications

a. Treatment of neurological disorders
b. Building block in the synthesis of bioactive molecules

Additional Activities

a. Antioxidant activity
b. Antifungal activity

Further Research

Pharmaceutical and medicinal applications

Upstream product

• 89638-21-1 1-(2-fluorophenyl)-prop-2-en-1-one 
• 100-46-9 benzylamine 
• 551-93-9 2-aminoacetophenone 
• 1352449-03-6 1-(2-((2-iodobenzyl) (methyl)amino)phenyl)-ethan-1-one 
• 1859-75-2 o-(methylamino)acetophenone 
• 5159-41-1 2-iodobenzyl alcohol 
• 40400-13-3 2-Iodobenzyl bromide 
• 4295-36-7 2,3-dihydroquinolin-4(1H)-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 1034770-78-9 1-benzyl-2,3-dihydroquinolin-4(1H)-one O-methyl oxime 
• 1261165-52-9 (E)-tert-butyl 3-(1-benzyl-4-oxo-1,4-dihydroquinolin-3-yl)acrylate 

Relevant academic research and scientific papers

C–C bond-forming reactions of ground-state aryl halides under reductive activation

Under basic conditions aryl halides can undergo SRN1 reactions, BHAS reactions and benzyne formations. Appropriate complex substrates afford an opportunity to study inherent selectivities. SRN1 reactions are usually favoured under ph

1-Alkyl-2,3-dihydro-4(1H)-quinolinones by a tandem Michael-SNAr annulation reaction

(Chemical Equation Presented) A tandem Michael-SNAr annulation reaction has been developed for the synthesis of 1-alkyl-2,3-dihydro-4(1H)- quinolinones. Success in the reaction followed expected electronic effects for the final SNAr

ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF

The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.