39549-22-9

Usage

InChI:InChI=1/C10H12O5/c1-2-15-8-5-6(3-4-7(8)11)9(12)10(13)14/h3-5,9,11-12H,2H2,1H3,(H,13,14)

Upstream product

• 66644-03-9 1-(3-ethoxy-4-hydroxy-phenyl)-2,2,2-trichloro-ethanol 
• 94-71-3 2-Ethoxyphenol 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 579494-69-2 acetoxy-(4-acetoxy-3-ethoxyphenyl)-acetic acid 
• 80018-50-4 [3-(ethyloxy)-4-hydroxyphenyl]acetic acid 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents

In this paper, we designed and synthesized a series of novel phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents. The best compound 10 had relatively high affinity for the GABAA receptor and low affinity for thirteen other off-target receptors. In three animal models (mice, rats, and rabbits), compound 10 exerted potent hypnotic effects (HD50 = 5.2 mg/kg in rabbits), comparable duration of the loss of righting reflex (LORR), and significant shorter recovery time (time to walk) than propanidid. Furthermore, compound 10 (TI = 18.1) showed higher safety profile than propanidid (TI = 14.7) in rabbits. Above results suggested that compound 10 may have predictable and rapid recovery profile in anesthesia.

Phenyl acetate compound with improved pharmacokinetic performance and anaesthetic performance

The invention relates to a phenyl acetate compound with improved pharmacokinetic performance and anaesthetic performance. The invention provides the phenyl acetate compound represented by a formula (I), wherein R1 is L1OC(O)L2, L1 is a substituted or unsu

Pharmaceutical compositions of short-acting sedative hypnotic agent

The invention provides pharmaceutical compositions comprising a phenylacetic acid ester compound useful for inducing or maintaining general anesthesia or sedation in mammals, methods for preparing such compositions, and methods for inducing or maintaining

Process for preparing aromatic hydroxyaldehydes

Aromatic hydroxy aldehydes are prepared by the simultaneous oxidation and decarboxylation of hydroxy aryl glycolic acids by reacting same with oxidizing agents in aqueous-acid medium.