80018-50-4

Usage

Uses

Used in Pharmaceutical Industry:
3-ETHOXY-4-HYDROXYPHENYLACETIC ACID is used as an intermediate in the synthesis of pharmaceuticals for its potential therapeutic benefits. It is valued for its antioxidant and anti-inflammatory properties, which contribute to the development of treatments for conditions such as diabetes and cardiovascular diseases.
Used in Flavoring Agents:
In the food industry, 3-ETHOXY-4-HYDROXYPHENYLACETIC ACID is used as a flavoring agent due to its characteristic aromatic properties. Its presence in various plant sources makes it a natural and appealing addition to enhance the taste and aroma of food products.
Used in Antioxidant Applications:
3-ETHOXY-4-HYDROXYPHENYLACETIC ACID is utilized as an antioxidant in both the pharmaceutical and food industries. Its ability to combat oxidative stress makes it a beneficial component in formulations aimed at preventing or treating diseases associated with oxidative damage.
Used in Anti-Inflammatory Formulations:
Leveraging its anti-inflammatory properties, 3-ETHOXY-4-HYDROXYPHENYLACETIC ACID is used in the development of anti-inflammatory formulations. This application is particularly relevant in the pharmaceutical industry for managing inflammation-related conditions.

InChI:InChI=1/C10H12O4/c1-2-14-9-5-7(6-10(12)13)3-4-8(9)11/h3-5,11H,2,6H2,1H3,(H,12,13)

Upstream product

• 358742-92-4 methyl 2-(3-ethoxy-1-methyloxycarbonyl-4-oxo-2,5-cyclohexadienyl)acetate 
• 39549-22-9 3-ethoxy-4-hydroxymandelic acid 
• 94-71-3 2-Ethoxyphenol 

Downstream Products

• 1224591-24-5 C₁₉H₂₀N₂O₇ 

Relevant academic research and scientific papers

Design, synthesis, and evaluation of phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents

In this paper, we designed and synthesized a series of novel phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents. The best compound 10 had relatively high affinity for the GABAA receptor and low affinity for thirteen other off-target receptors. In three animal models (mice, rats, and rabbits), compound 10 exerted potent hypnotic effects (HD50 = 5.2 mg/kg in rabbits), comparable duration of the loss of righting reflex (LORR), and significant shorter recovery time (time to walk) than propanidid. Furthermore, compound 10 (TI = 18.1) showed higher safety profile than propanidid (TI = 14.7) in rabbits. Above results suggested that compound 10 may have predictable and rapid recovery profile in anesthesia.

Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants

4-Hydroxyphenylacetic acid amides and 4-hydroxycinnamamides were synthesized and their antioxidant and neuroprotective activities were evaluated. Among the prepared compounds, 6f, 6g, 8b, and 9 exhibited potent inhibition of lipid peroxidation in rat brain homogenates, and marked DPPH radical scavenging activities. Furthermore, 6f, 6g, and 9 exhibited neuroprotective action against the oxidative damage induced by the exposure of primary cultured rat cortical cells to H2O2, xanthine/xanthine oxidase, or Fe2+/ascorbic acid. Based on these results, we found that 6f was the most potent antioxidant among the compounds tested.

Synthesis of 3-alkoxy-4-hydroxyphenylacetic acids from methyl 3-alkoxybenzoates

3-Alkoxy-4-hydroxyphenylacetic acids 4 were obtained from 3-alkoxyl-substituted methyl benzoates 1 by reductive alkylation, followed by allylic oxidation and hydrolysis.