395655-65-9Relevant academic research and scientific papers
Could Dissecting the Molecular Framework of β-Lactam Integrin Ligands Enhance Selectivity?
Martelli, Giulia,Baiula, Monica,Caligiana, Alberto,Galletti, Paola,Gentilucci, Luca,Artali, Roberto,Spampinato, Santi,Giacomini, Daria
, p. 10156 - 10166 (2019)
By dissecting the structure of β-lactam-based ligands, a new series of compounds was designed, synthesized, and evaluated toward integrins αvβ3, α5β1, and α4β1. New selective ligands with a
Synthesis and conformational studies on 3-o-tolylhydantoins by NMR and molecular modeling: Dipole-π attractions in peptides and proteins
Park, Sang Hyun,Bose, Ajay K.
, p. 1917 - 1925 (2007/10/03)
5-Pentafluorobenzyl-3-o-tolylhydantoin (2) was synthesized for reducing this π-electron density, and NMR studies have shown that we have succeeded in changing the conformation of 2 into an extended system instead of the folded conformation for the non-fluorinated compound, 5-benzyl-3-o-tolylhydantoin (1). Molecular modeling has also confirmed the extended structure for 2. An approach has been found for possibly modulating the physiological activity of peptides containing aromatic amino acids.
