56182-14-0Relevant articles and documents
Synthesis and conformational studies on 3-o-tolylhydantoins by NMR and molecular modeling: Dipole-π attractions in peptides and proteins
Park, Sang Hyun,Bose, Ajay K.
, p. 1917 - 1925 (2001)
5-Pentafluorobenzyl-3-o-tolylhydantoin (2) was synthesized for reducing this π-electron density, and NMR studies have shown that we have succeeded in changing the conformation of 2 into an extended system instead of the folded conformation for the non-fluorinated compound, 5-benzyl-3-o-tolylhydantoin (1). Molecular modeling has also confirmed the extended structure for 2. An approach has been found for possibly modulating the physiological activity of peptides containing aromatic amino acids.