39573-20-1

Usage

Uses

Used in Pharmaceutical Industry:
(5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE is used as a building block for the synthesis of various drugs and pharmaceutical ingredients. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Cancer Treatment Research:
In the field of cancer treatment, (5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE is studied for its potential role in targeting and treating cancer cells. Its specific interactions with biological systems may contribute to the development of novel therapeutic strategies against cancer.
Used as an Anti-Inflammatory Agent:
(5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE has also been explored for its anti-inflammatory properties, which could be beneficial in the treatment of various inflammatory conditions and diseases.
Used in Organic Synthesis:
As a reagent in organic synthesis, (5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE is utilized for the creation of a wide range of chemical products, contributing to the advancement of chemical research and development.
Used in Medicinal Chemistry and Drug Discovery Research:
(5-BROMO-2-METHYLAMINO-PHENYL)-PHENYL-METHANONE's potential applications extend to medicinal chemistry and drug discovery research, where it may be employed to identify new drug candidates or optimize existing ones for improved efficacy and safety.

Upstream product

• 16029-98-4 trimethylsilyl iodide 
• 63335-21-7 C₁₄H₁₁BrNO⁽¹⁺⁾*CH₃O₄S^(1-) 
• 39859-36-4 2-amino-5-bromobenzophenone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 6911-87-1 4-bromo-N-methylaniline 
• 108-88-3 toluene 
• 937-23-5 4-bromo-N-nitroso-N-methylaniline 
• 179897-89-3 5-Bromo-2-fluoro-benzonitrile 
• 106874-91-3 5-bromo-2-(methylamino)benzonitrile 
• 100-58-3 phenylmagnesium bromide 
• 611-73-4 Benzoylformic acid 
• 94579-32-5 2-N-Tosylamino-5-bromobenzophenone 
• 94863-99-7 N-(2-benzoyl-4-bromophenyl)-N,4-dimethylbenzenesulfonamide 

Downstream Products

• 104542-58-7 2-methyl(N-carbobenzoxy-α-alanyl-glycyl)amido-5-bromobenzophenone 
• 1610460-74-6 3-benzyl-5-bromo-1-methyl-3-phenylindolin-2-one 
• 63563-58-6 8-bromo-1-methyl-6-phenyl-3,4-dihydro-1H-benzo[1,5]diazocin-2-one 

Relevant academic research and scientific papers

Method for synthesizing 2-aminobenzophenone compound

The invention discloses a method for synthesizing a 2-aminobenzophenone compound, and belongs to the technical field of organic synthesis. According to the key point of the technical scheme, the method comprises the following steps that an N-nitroso-2-ami

Enantioselective Intramolecular Copper-Catalyzed Borylacylation

An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon–boron bond provides a platform for a wide array of diversification.

Synthesis of 2-aminobenzophenones through acylation of anilines with α-oxocarboxylic acids assisted by: Tert -butyl nitrite

In this paper, a regioselective, efficient and convenient synthesis of 2-aminobenzophenones through acylation of anilines with α-oxocarboxylic acids assisted by tert-butyl nitrite is presented. Interestingly, tert-butyl nitrite acts as not only an efficient and mild nitrosation reagent, but also a sustainable oxidant required in the Pd(ii)-catalyzed decarboxylative acylation. Meanwhile, the NO unit turned out to be an easily introduced and readily removable directing group for the regioselective acylation.

Silica gel-mediated hydroamination/semipinacol rearrangement of 2-alkylaminophenylprop-1-yn-3-ols: Synthesis of 2-oxindoles from alkynes and 1-(2-aminophenyl) ketones

2-Alkylaminophenylprop-1-yn-3-ols, prepared from the lithium diisopropylamide (LDA)- mediated 1,2-addition of alkynes to 1-(2-aminophenyl) ketones, can be converted to 3,3-disubstituted 2-oxindoles by using silica gel in n-hexane/ ethyl acetate (20:1 v/v) as the reaction medium. The utility of the approach as a potential scale-up strategy for the synthesis of 2-oxindoles was exemplified by the large-scale synthesis of one adduct in excellent yield. The synthetic applicability of this chemistry was also demonstrated by the recycling of the silica gel up to 8 times with no apparent loss of activity being observed for the same example.

Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: A traceless approach to synthesize N-alkyl-2-aminobenzophenones

A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in anilines can act as the traceless directing groups while toluene derivatives can serve as effective acyl precursors under mild reaction conditions.

Bakers' yeast-catalyzed reductive cleavage of 3-aryl-2,1-benzisoxazoles and its quaternary salts: An efficient green synthesis of 2-aminobenzophenones

3-Aryl-2,1-benzisoxazoles and its salts underwent reductive cleavage of the N-O bond leading to 2-aminobenzophenones with bakers' yeast under non-fermenting conditions in aqueous media. The procedure gives excellent yields of 2-alkylamino- and 2-aminobenzophenones.

A convenient method for the production of ortho-amino and N-alkylaminobenzophenones

ortho-Amino and N-alkylaminobenzophenones 3 have been prepared in good yields by the reductive cleavage of 2,1-benzisoxazole and its salts with Zn-AlCl3*6H2O/THF system.

A Convenient Preparation of Alkylaminobenzophenones from 2,1-Benzisoxazolium Salts and Iodotrimethylsilane

2-Alkylaminobenzophenones (2) have been prepared in good yields from 2,1-benzisoxazolium salts (1) and iodotrimethylsilane.