396073-62-4Relevant articles and documents
Synthesis of diaminobutane derivatives as potent Ca2+-permeable AMPA receptor antagonists
Yoneda, Yoshiyuki,Kawajiri, Shinichi,Sugimura, Masunobu,Osanai, Ken,Kito, Fusako,Ota, Emi,Mimura, Tetuya
, p. 2663 - 2666 (2007/10/03)
We synthesized diaminobutane derivatives as potent Ca2+-permeable AMPA receptor antagonists with non-hypotensive activity. Compound 10c showed selective Ca2+-permeable AMPA receptor antagonist activity and neuroprotective effects in transient global ischemia models in gerbils.