3962-41-2Relevant academic research and scientific papers
Fe(HSO4)3 : An efficient, heterogeneous and reusable catalyst for C-alkylation of β-dicarbonyl compounds
Khafajeh, Samaneh,Akhlaghinia, Batool,Rezazadeh, Soodabeh,Eshghi, Hossein
, p. 1903 - 1912 (2015/02/05)
Fe(HSO4)3(FHS) was used as an efficient catalyst for the heterogeneous addition of a series of benzylic and allylic alcohols to various β-dicarbonyl compounds, which afforded moderate to excellent yields of C-alkylated products in 1,2-dichloroethane. In comparison with the previous methods, the present research surprisingly exhibited higher reaction yields without formation of any by-products which could be formed by self-condensation of alcohols. Moreover, the catalyst can be readily recovered and reused up to five times with almost maintained reactivity and yields.
Carbon-based leaving group in substitution reactions: Functionalization of sp3-hybridized quaternary and tertiary benzylic carbon centers
Mahoney, Stuart J.,Lou, Tiantong,Bondarenko, Ganna,Fillion, Eric
, p. 3474 - 3477 (2012/09/05)
Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic Csp 3-Csp3 bonds into Csp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).
ONE POT SYNTHESIS OF MONOSUBSTITUTED ISOPROPYLIDENE MALONATES
Huang, Xian,Xie, Linghong
, p. 1701 - 1708 (2007/10/02)
Monosubstituted isopropylidene malonates have been synthesized from Meldrum's acid and carbonyl compounds in the presence of sodium hydrogentelluride as a one pot reaction.
COPPER-CATALYZED CONJUGATE ADDITION OF GRIGNARD REAGENTS TO ISOPROPYLIDENE ALKYLIDENEMALONATES
Huang, Xian,Chan, Cheng-Chu,Wu, Quin-Li
, p. 75 - 76 (2007/10/02)
A new method for the synthesis of isopropylidene alkylmalonates involving conjugate addition of Grignard reagents to isopropylidene alkylidene malonates was developed.
