87057-91-8

Basic information

• Product Name: 5-benzhydryl-2,2,5-trimethyl-1,3-dioxane-4,6-dione
• Synonyms: 5-benzhydryl-2,2,5-trimethyl-1,3-dioxane-4,6-dione
• CAS NO: 87057-91-8
• Molecular Weight: 324.376
• Mol File: 87057-91-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-benzhydryl-2,2,5-trimethyl-1,3-dioxane-4,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-benzhydryl-2,2,5-trimethyl-1,3-dioxane-4,6-dione(87057-91-8)
• EPA Substance Registry System: 5-benzhydryl-2,2,5-trimethyl-1,3-dioxane-4,6-dione(87057-91-8)

Safety Data

• Hazardous Substances Data: 87057-91-8(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 3962-41-2 5-benzhydryl-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 74-88-4 methyl iodide 
• 1214-54-6 5-benzylidene Meldrum's acid 
• 2033-24-1 cycl-isopropylidene malonate 

Downstream Products

• 612-00-0 1,1'-ethylidenebis-benzene 
• 4286-85-5 4,4-diphenyl-1-butene 

Relevant articles and documents

Carbon-based leaving group in substitution reactions: Functionalization of sp3-hybridized quaternary and tertiary benzylic carbon centers

Lewis acid promoted substitution reactions employing Meldrum's acid and 5-methyl Meldrum's acid as carbon-based leaving groups are described which transform unstrained quaternary and tertiary benzylic Csp 3-Csp3 bonds into Csp3-X bonds (X = C, H, N). Importantly, this reaction has a broad scope in terms of both suitable substrates and nucleophiles with good to excellent yields obtained (typically >90%).