39626-49-8Relevant academic research and scientific papers
Tandem blaise-alkenylation with unactivated alkynes: One-pot synthesis of α-vinylated β-enaminoesters from nitriles
Chun, Yu Sung,Ko, Young Ok,Shin, Hyunik,Lee, Sang-Gi
supporting information; experimental part, p. 3414 - 3417 (2009/12/03)
The in situ generated Blaise reaction intermediate, a zinc bromide complex of β-enaminoester, reacts with various unactivated terminal alkynes and an internal alkyne under mild conditions to afford α-vinylated β-enaminoesters in good to excellent yields.
Novel Approach to the Ring-Opening of 4-Isoxazolines: One-Pot Synthesis of α,β-Enones
Chiacchio, Ugo,Liguori, Angelo,Rescifina, Antonio,Romeo, Giovanni,Rossano, Flavia,et al.
, p. 123 - 132 (2007/10/02)
Treatment of 4-isoxazoline derivatives with methyl iodide affords α,β-enones in excellent yields.The novel rearrangement pathway, through an intermediate isoxazolinium salt, is interpretable on the basis of the base removal of the hydrogen atom at N-CH3 group.
