39629-29-3

Upstream product

• 31469-16-6 1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 100-52-7 benzaldehyde 
• 62-53-3 aniline 

Relevant academic research and scientific papers

An efficient and mild bismuth triflate-catalysed three-component Mannich-type reaction

In the presence of a catalytic amount of Bi(OTf)3·4H 2O, aldehydes together with amines react with silyl enolates to afford the corresponding Mannich-type adducts smoothly. A wide variety of silyl enolates derived from ketones, as well as esters and thioesters, react rapidly to afford the β-amino ketones or the β-amino esters in high yields (up to 94%). The Royal Society of Chemistry.

Recyclable polymeric π-acid catalyst effective on Mannich-type reaction in water

Polymer-supported dicyanoketene acetal (poly-DCKA-1), synthesized by copolymerization of a DCKA bearing a 4-vinylbenzyl group with ethyleneglycol dimethacrylate, was found to be an excellent recyclable catalyst for the three-component Mannich-type reaction of aldehydes, aromatic amines, and TMS enolate of ethyl isobutyrate in water as the sole solvent.

Synthesis of β-amino esters by bismuth triflate catalyzed three-component Mannich-type reaction

We have developed an efficient, bismuth-catalyzed, Mannich-type three-component reaction by combining the corresponding aldehyde, amine, and silyl ketene acetal. The reaction proceeds rapidly and affords the corresponding β-amino esters in high yields (up

Mannich-type reaction catalyzed by dicyanoketene ethylene acetal and the related polymer-supported π-acid: Aldimine-selective reactions in the coexistence of aldehydes

Mannich-type reaction of aldimines and enolsilyl ethers proceeded with excellent aldimine-selectivity in the coexistence of aldehydes by means of dicyanoketene ethylene acetal (DCKEA) and the related polymer-supported dicyanoketene acetal as a recyclable π -acid catalyst.