39633-53-9

Upstream product

• 21411-81-4 2-isopropyl-5-methyl-cyclohexylamine 
• 75-44-5 phosgene 
• 34048-57-2 (-)-(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexaneammonium chloride 
• 16052-40-7 (-)-(1R,3R,4S)-4-isopropyl-1-methylcyclohexane-3-carboxylic acid 
• 107535-12-6 (1S,2S,4R)-2-azido-1-isopropyl-4-methylcyclohexane 
• 34048-58-3 N-((1R)-neomenthyl)-formamide 
• 1446348-69-1 C₁₁H₁₉N 

Relevant academic research and scientific papers

A biomimetic approach to the synthesis of the core structure of the marine sponge terpene halichonadin G

A pathway for the biosynthesis of halichonadin G involving the unique action of ugiase and isocyanide oxidase is proposed. This hypothesis was tested in a biomimetic approach to the synthesis of the core structural unit of this marine sponge terpene, which relies on a key Ugi coupling reaction and an isocyanide-to-isocyanate oxidative transformation. The results of this effort demonstrate that the biomimetic strategy can be employed to construct the core structure of halichonadin G in an efficient manner. A unique pathway for the biosynthesis of the marine sponge terpene halichonadin G is proposed. On the basis of this proposal, a biomimetic approach involving a Ugi coupling reaction is designed and applied to the efficient construction of the core structure of halichonadin G. Copyright

Compositions and methods for the treatment of disease associated with Trp-p8 expression

Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

Synthesis and Characterization of Enantiomerically Pure Menthylamines and Their Isocyanates

A synthetic protocol for optically pure (-)-menthylamine, (-)-8-methylmenthylamine, and the novel (-)-8-phenylmenthylamine is presented including a detailed characterization of these compounds and their isocyanates.