5-BROMO-2-HYDROXYBENZOHYDRAZIDE

Base Information

• Chemical Name: 5-BROMO-2-HYDROXYBENZOHYDRAZIDE
• CAS No.: 39635-10-4
• Molecular Formula: C7H7 Br N2 O2
• Molecular Weight: 231.049
• Hs Code.: 2928000090
• Mol file: 39635-10-4.mol

Synonyms:Salicylicacid, 5-bromo-, hydrazide (6CI,7CI); 5-Bromosalicylhydrazide; NSC 409918

Chemical Property of 5-BROMO-2-HYDROXYBENZOHYDRAZIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 75.35000
• Density: 1.756g/cm³
• LogP: 1.84940

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-hydroxybenzohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-HYDROXYBENZOHYDRAZIDE

There total 3 articles about 5-BROMO-2-HYDROXYBENZOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-hydroxy-benzoic acid methyl ester (4068-76-2) → 2-hydroxy-5-bromobenzohydrazide (39635-10-4)

Guidance literature:

With hydrazine hydrate;

DOI:10.1021/jo50012a013

Reference yield:

5-bromosalicyclic acid (89-55-4) → 2-hydroxy-5-bromobenzohydrazide (39635-10-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 8 h / 0 °C / Reflux

2: hydrazine hydrate / ethanol / 80 - 90 °C

With thionyl chloride; hydrazine hydrate; In ethanol;

DOI:10.1007/s00044-014-0909-0

Reference yield:

→ 2-hydroxy-5-bromobenzohydrazide (39635-10-4)

Guidance literature:

5-Bromsalicylsaeuremethylester, N2H4*H2O;

upstream raw materials:

5-bromo-2-hydroxy-benzoic acid methyl ester

5-bromosalicyclic acid

Downstream raw materials:

piperonal-(5-bromo-2-hydroxy-benzoylhydrazone)

5-bromo-2-hydroxy-benzoic acid-(4-chloro-benzylidenehydrazide)

(Z)-3-(5'-bromosalicyloylhydrazinocarbonyl)prop-2-enoic acid

5-bromo-2-(ethoxymethoxy)-N'-((1E)-1-(1H-indol-2-yl)ethylidene)benzohydrazide

Refernces

• 1、 Xing, Man,Zhao, Ting-Ting,Ren, Yu-Jia,Peng, Na-Na,Yang, Xian-Hui,Li, Xi,Zhang, Hui,Liu, Gao-Qi,Zhang, Li-Rong,Zhu, Hai-Liang. "Synthesis, biological evaluation, and molecular docking studies of pyrazolyl-acylhydrazone derivatives as novel anticancer agents". . p. 3274 - 3286. Retrieved 2014/06/24.