39650-67-4Relevant articles and documents
Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease
Keri, Rangappa S.,Quintanova, Catarina,Marques, Sérgio M.,Esteves, A. Raquel,Cardoso, Sandra M.,Santos, M. Amélia
, p. 4559 - 4569 (2013/07/26)
Alzheimer's disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Aβ) aggregat
Process for preparing a 2(ω-aminoalkyl)-1,3-heterocyclic compounds
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, (2008/06/13)
2-(ω-AMINOALKYL)-1,3-HETEROCYCLIC COMPOUNDS ARE PREPARED BY REACTING A COMPOUND SELECTED FROM THE GROUP OF A DIAMINE, AN AMINOHYDROXY AND AN AMINOTHIOL COMPOUND, SAID COMPOUND HAVING THE FORMULA: EQU1 wherein EQU2 A is a bivalent chain of 2 or 3 carbon atoms, which can also be part of a bivalent, optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical, and X is oxygen, sulphur or the group EQU3 wherein R7 is as defined herein with a lactam having the formula EQU4 WHEREIN B is selected from the group of a single bond, oxygen, sulphur, the group EQU5 wherein R6 is as defined herein, and arylene, R1, r2, r3 and R4, which may be the same or different, are selected from the group of hydrogen, halogen, nitro and optionally substituted aliphatic, cycloaliphatic, araliphatic and aromatic, R5, r6 and R7, which may be the same or different, are selected from the group of hydrogen and optionally substituted aliphatic, cycloaliphatic, araliphatic and aromatic, and n and m, which may be the same or different, are intergers of from 1 to 14, with the proviso that the sum of n and m does not exceed 15, At a temperature of from 100° to 300°C in the presence of at least a catalytic quantity of an acid and/or an acid catalyst.
