396652-38-3Relevant academic research and scientific papers
INHIBITORS OF ENL/AF9 YEATS
-
Paragraph 00266-00267, (2021/06/26)
Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.
Iron-Catalyzed Intramolecular C—H Amidation of N-Benzoyloxyureas
Zhong, Dayou,Wu, Lin-Yang,Wang, Xing-Zhen,Liu, Wen-Bo
supporting information, p. 855 - 858 (2021/02/16)
A redox-neutral Fe-catalyzed intramolecular C—H amidation of N-benzoyloxyureas is described. This methodology employs a simple iron complex in situ generated from Fe(OTf)2 and bipyridine as the catalyst and N-benzoyloxyureas as the nitrene prec
KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
-
Paragraph 0021; 0206; 0207, (2019/06/05)
The present invention is directed to kinase inhibitor compounds having the following structure: or a stereoisomer, pharmaceuticallyacceptable salt, oxide, or solvate thereof, where R1, R2, X, n, R3, Y, Z, R4, R
BICYCLIC HYDROXAMIC ACIDS USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY
-
Page/Page column 81, (2017/07/14)
A compound of formula (Ia) or (Ib) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of a histone deacetylase, and as such is useful in terepy, e.g. in the treatment of autoimmune disorders, mental disorders, neurodegenerative disorders, and hyperproliferative disorders.
HETEROARYL INHIBITORS OF PAD4
-
Paragraph 00255-00257, (2017/09/15)
The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
Substituted Pyran Derivatives
-
Paragraph 0166, (2014/10/29)
Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter system
SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS
-
Page/Page column 32-33; 38-40, (2008/12/06)
The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating mammals suffering from the condition of being overweight.
BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR
-
Page/Page column 34, (2010/11/27)
This invention is directed to a compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula (I), a process of preparation of a compound of formula (I), a method o
