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Usage

Uses

Used in Pharmaceutical Industry:
p-Menthane-3-carboxylic acid is used as a pharmaceutical agent for its analgesic and anti-inflammatory properties, making it a potential candidate for the development of new pain-relief medications. It is particularly useful in treating inflammatory conditions such as arthritis and neuropathic pain.
Used in Cosmetics Industry:
p-Menthane-3-carboxylic acid is used as an ingredient in cosmetics for its antioxidant properties, which can help protect the skin from oxidative stress and promote overall skin health.
Used in Food Industry:
p-Menthane-3-carboxylic acid is used as a natural preservative in the food industry due to its anti-microbial properties, helping to extend the shelf life of food products and maintain their quality.
Used in Antioxidant Applications:
p-Menthane-3-carboxylic acid is used as an antioxidant agent to protect cells from oxidative damage, which can contribute to various health issues and the aging process.
Used in Anti-microbial Applications:
p-Menthane-3-carboxylic acid is used as an anti-microbial agent to inhibit the growth of harmful microorganisms, making it useful in various applications such as food preservation, cosmetics, and pharmaceuticals.

InChI:InChI=1/C11H20O2/c1-7(2)9-5-4-8(3)6-10(9)11(12)13/h7-10H,4-6H2,1-3H3,(H,12,13)

Upstream product

• 28953-96-0 2-chloro-1-isopropyl-4-methyl-cyclohexane 
• 54556-12-6 2-isopropyl-5-methyl-cyclohexanecarbonitrile 
• 124-38-9 carbon dioxide 
• 65560-17-0 2-isopropyl-5-methyl-cyclohexanecarboxylic acid amide 
• 39711-79-0 WS-3 
• 15719-64-9 methylammonium carbonate 
• 463-79-6 carbonic-acid 

Downstream Products

• 1845-44-9 2-isopropyl-5-methyl-cyclohexanecarbaldehyde 
• 1119711-29-3 (2S,5R)-N-[4-(2-Amino-2-oxoethyl) phenyl]-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide 
• 92371-33-0 DL-Acetoxymethyl-menthyl-⁽³⁾-keton 
• 91637-83-1 DL-Diazomethyl-menthyl-⁽³⁾-keton 
• 92037-60-0 DL-Hydroxymethyl-menthyl-⁽³⁾-keton 
• 91883-21-5 DL-Chlormethyl-(menthyl-3)-keton 
• 39668-87-6 2-isopropyl-5-methylcyclohexanecarbonyl chloride 
• 65560-17-0 2-isopropyl-5-methyl-cyclohexanecarboxylic acid amide 

Relevant academic research and scientific papers

Process for preparing alicyclic carboxylic acid compounds

A process for preparing at least one alicyclic carboxylic acid compound by Grignard reaction, the process comprising: reacting magnesium and at least one alicyclic halide compound in at least one solvent to produce at least one alicyclic Grignard reagent;concurrently adding carbon dioxide to the magnesium, the alicyclic halide compound, the solvent, and the alicyclic Grignard reagent, while the alicyclic Grignard reagent is still being produced, to form at least one alicyclic carboxylate magnesium salt; andhydrolyzing the alicyclic carboxylate magnesium salt to form the alicyclic carboxylic acid compound;wherein the alicyclic Grignard reagent and the alicyclic carboxylate magnesium salt are prepared in a one-pot synthesis.

Menthylcarboxamides and Their Use as Cooling Agents

Described is a new cooling agent represented by Structure I and compositions with known coolers having cooling properties and the application of Structure I in foodstuffs and chewing gum:

Small-molecule modulators of TRP-P8 activity

Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.

Metal Alkoxide Modified Organometallic Reagents. Preparation and Stability of Organolithium Reagents in Tetrahydrofuran in the Presence of Magnesium 2-Ethoxyethoxide

The metalating ability of alkyllithium reagents and their tendency to cleave THF are greatly diminished in the presence of magnesium 2-ethoxyethoxide, 1.Advantage may be taken of this to generate organolithium reagents in THF in the presence of 1 under conditions not normally favorable to their stability.Thus, by reaction with metallic lithium in the presence of 1 in THF, the compounds RX (R = n-Bu, s-Bu, t-Bu, cyclohexyl, menthyl, p-methoxyphenyl, o-(methoxymethyl)phenyl; X = Cl, Br) have been converted to the corresponding organometallic reagents.In the absence of 1 the alkyllithium reagents formed react with the solvent, resulting in reduced yields and often alternative products.In the case of the preparation of the arylmetal reagents the presence of 1 suppresses either subsequent orthometalation (R = p-methoxyphenyl) or Wittig rearrangement (R = o-(methoxymethyl)phenyl) to give a clean replacement of halogen by the metal.The presence of THF is also tolerated in the preparation of these two arylmetal reagents by halogen-metal exchange using n-butyllithium in the presence of 1 whereas if 1 is absent little or none of the desired product is obtained.

Synthesis of N-t-butyl-p-menthane-3-carboxamide

This invention provides an efficient two-step reaction sequence for producing N-t-butyl-p-menthane-3-carboxamide. The process involves forming 3-p-menthylmagnesium halide, and reacting the 3-p-menthylmagnesium halide with t-butyl isocyanate to form the product.