396716-21-5

Basic information

• Product Name: Benzamide, N-[2-(aminothioxomethyl)phenyl]-4-chloro-N-methyl-
• CAS NO: 396716-21-5
• Molecular Formula: C15H13ClN2OS
• Molecular Weight: 304.8
• Mol File: 396716-21-5.mol

Chemical Properties

• CAS DataBase Reference: Benzamide, N-[2-(aminothioxomethyl)phenyl]-4-chloro-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-[2-(aminothioxomethyl)phenyl]-4-chloro-N-methyl-(396716-21-5)
• EPA Substance Registry System: Benzamide, N-[2-(aminothioxomethyl)phenyl]-4-chloro-N-methyl-(396716-21-5)

Safety Data

• Hazardous Substances Data: 396716-21-5(Hazardous Substances Data)

Upstream product

• 32600-73-0 2-methylaminothiobenzamide 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 74375-03-4 1-methyl-2-(4-chlorophenyl)quinazolin-4(3H)-one 
• 396716-31-7 1-methyl-2-(4-chlorophenyl)quinazoline-4(3H)-thione 

Relevant articles and documents

Synthesis of substituted 2-benzoylaminothiobenzamides and their ring closure to substituted 2-phenylquinazoline-4-thiones

Acylation of 2-aminothiobenzamide or 2-methylaminothiobenzamide with substituted benzoyl chlorides has been used to synthesise the corresponding 2-benzoyl-aminothiobenzamides whose subsequent sodium methoxide-catalysed ring closure gives the corresponding quinazoline-4-thiones. These compounds were characterised by means of their 1H- and 13C-NMR spectra. The preferred tautomeric form of selected compounds has been discussed on the basis of their 13C-NMR, IR and Raman spectra. It has been found that in the given medium 1-methyl-quinazoline-4-thiones undergo a replacement of the sulphur substituent by oxygen giving 1-methyl-quinazoline-4-ones. In strong acid media, 2-benzoylaminothiobenzamide is cyclised through its sulphur atom to give 2-phenylbenzo[d-1,3]thiazin-4-one.