39672-00-9

Upstream product

• 120-92-3 cyclopentanone 
• 530-50-7 1,1-Diphenylhydrazine 

Downstream Products

• 226066-82-6 acetic acid 1-(1-cyclopenten-1-yl)-2,2-diphenylhydrazide 
• 39672-13-4 N-[2-(N',N'-Diphenyl-hydrazino)-cyclopent-1-enecarbothioyl]-4-methyl-benzenesulfonamide 
• 226066-70-2 trifluoroacetic acid 1-(1-cyclopenten-1-yl)-2,2-diphenylhydrazide 

Relevant academic research and scientific papers

One-pot synthesis of indoles from ketones and hydrazines under mild reaction conditions

A facile one-pot method is presented for the synthesis of indoles via condensation of ketone with hydrazine followed by acylation and rearrangement. This convenient synthetic method provides an easy and simple access to indoles.

Photoredox Fischer Indole Synthesis

Visible light photoredox conditions were applied to the traditional Fischer indole synthesis. N, N -Diarylhydrazones were efficiently converted into the corresponding indoles even at 30 °C by treatment with bromotrichloromethane in the presence of Ru(bpy) 3 Cl 2 ·6H 2 O as the photocatalyst. Electrochemical study revealed the viability of oxidative quenching cycle for the photocatalysis, which set the basis for proposing the redox-based reaction mechanism.

Radical cyclisations of imines and hydrazones

Radical cyclisation of sp3 carbon-centred radicals onto imines and hydrazones provides a new method for the synthesis of 5- and 6-membered ring nitrogen heterocycles. Cyclisation onto the electrophilic carbon of the C=N group and 5-exo stereoelectronic selectivity are the dominating mechanistic parameters. The C-centred radical intermediates were generated from benzeneselenyl precursors using Bu3SnH.